Anti-Inflammatory and Antioxidant Actions of Methyl Jasmonate Are Associated with Metabolic Modifications in the Liver of Arthritic Rats

Figure 8

Schematic representation of the events modifying oxidative stress and metabolism in the liver of arthritic rats and actions of methyl jasmonate (MeJA). The scheme is discussed in the text and is based on the results of the current work and on previously published data. The symbol ⇑ means upregulation and ⇓ downregulation. Black arrows indicate events in the absence of MeJA, and red arrows indicate the effects of MeJA. TNF-α: tumor necrosis factor alpha; IL-1: interleukin 1; GSH: reduced glutathione; GSSG: oxidized glutathione; MPH: macrophages; LYM: lymphocytes; NEUTR: neutrophils; SYN: synoviocytes; ROS: reactive oxygen species.