Anti-Inflammatory and Antioxidant Actions of Methyl Jasmonate Are Associated with Metabolic Modifications in the Liver of Arthritic Rats

Table 1

Inflammatory parameters and number of blood and articular leukocytes. The number of leukocytes in the peripheral blood was measured before adjuvant induction (initial, at day 0) for the arthritic group (A) and at day 18 for all groups. The number of articular leukocytes was measured in the femorotibial hind joints at day 18. The initial paw volume was 1.6 ± 0.1 ml; Δvol of paws (paw edema) = volume at day 18 − initial volume. The score of secondary lesions (arthritic score) is defined in Section 2.4. A: nontreated arthritic rats; A corn oil: arthritic rats treated with corn oil; A75, A150, and A300: arthritic rats treated with 75, 150, and 300 mg·kg⁻¹ MeJA; IBU: arthritic rats treated with 30 mg·kg⁻¹ ibuprofen.

Parameters	Initial	A	A corn oil	A75	A150	A300	IBU
Δvol − injected paw (mL)	—	4.0 ± 0.3^a	3.5 ± 0.2^a	4.4 ± 0.3^a	4.0 ± 0.2^a	1.3 ± 0.2^b	1.6 ± 0.2^b
Δvol − noninjected (mL)	—	2.1 ± 0.3^a	2.0 ± 0.2^a	2.9 ± 0.2^a	2.6 ± 0.1^a	0.5 ± 0.1^b	0.3 ± 0.1^b
Arthritic score	—	5.0 ± 0.0^a	5.0 ± 0.0^a	5.0 ± 0.0^a	4.4 ± 0.2^a	4.4 ± 0.4^a	3.5 ± 0.3^a
	(at day 0)	Blood leukocytes (at day 18)
Total leukocytes (×10^3) (mm^3)^−1	13.1 ± 0.5^a	66.7 ± 9.9^b	47.2 ± 1.3^b	52.8 ± 6.4^b	52.8 ± 6.4^b	32.6 ± 2.4^c	34.6 ± 2.2^c
PMN cells (%)	15 ± 2^a	70 ± 3^b	64 ± 4^b	66 ± 3^b	66 ± 3^b	48 ± 6^c	62 ± 5^b
		Articular leukocytes (hind left joint)
Total leukocytes (×10^4) (mm^3)^−1	—	16.8 ± 3.2^a	13.7 ± 1.7^a	16.1 ± 1.8^a	2.0 ± 0.7^b	0.9 ± 0.3^c	3.9 ± 1.1^b
PMN cells (%)	—	53 ± 3^a	69 ± 6^a	62 ± 2^a	58 ± 23^b	61 ± 3^b	65 ± 3^b
		Articular leukocytes (hind right joint)
Total leukocytes (×10^4) (mm^3)^−1	—	6.9 ± 0.7^a	6.1 ± 1.5^a	6.5 ± 0.7^a	7.0 ± 1.5^a	2.3 ± 0.2^b	1.1 ± 0.4^b
PMN cells (%)	—	53 ± 1^a	61 ± 8^a	69 ± 2^a	60 ± 1^a	74 ± 3^a	69 ± 4^a

Data are of 5 animals. Values with different superscript letters in the same line are different.