A Comparative Evaluation of the Cytotoxic and Antioxidant Activity of Mentha crispa Essential Oil, Its Major Constituent Rotundifolone, and Analogues on Human Glioblastoma

Table 1

The IC₅₀ values of Mentha crispa essential oil and test compounds against U87MG cells.

Compounds	IC50 (mg/L)
PALC	78.376 ± 0.63
ROT	30.083 ± 0.81
EPER1	15.087 ± 0,58
EPER2	59.986 ± 0.79
(−)-HCAR	31.243 ± 0.66
(+)-HCAR	72.311 ± 0.85
MCEO	16.263 ± 0.58
PALD	14.888 ± 0.60
DOX	4.020 ± 0.32
Triton-X	8.186 ± 0.55

Data are presented as of four repetitions. Triton-X and doxorubicin (DOX) were used as positive controls.