Anti-Inflammatory Activity of Marine Ovothiol A in an In Vitro Model of Endothelial Dysfunction Induced by Hyperglycemia

Figure 5

Effect of ovothiol A on adhesion molecule membrane exposure in C- and GD-HUVECs. VCAM-1 (a) and ICAM-1 (b) membrane exposure in C- and GD-HUVECs untreated (basal) and incubated for 24 h with ovothiol A (50 μM) and then stimulated for 16 h with or without TNF-α (1 ng/mL). The results are expressed as fold increase (versus basal C-HUVECs) of the MFI ratio of surface exposure on the plasma membrane of VCAM-1 and ICAM-1 in non permeabilized cells (). ANOVA and Bonferroni multiple comparison test: in C- and GD-HUVECs. Student’s t-test: TNF-α GD- versus C-HUVECs.

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