Function and Regulation of Protein Kinase D in Oxidative Stress: A Tale of Isoforms

Figure 1

Domain organization and phosphorylation sites of PKD1/2/3 in oxidative stress conditions. Tyr phosphorylation sites are indicated with yellow-coloured circles, and Ser phosphorylation sites are indicated with red-coloured circles. “Direct evidence” indicates that the sites have been shown to be phosphorylated via immunoblotting with a site-specific antibody or via mass spectrometry. “Indirect evidence” indicates data obtained via site-directed mutagenesis or readouts dependent on general phosphorylation (such as PhosTag gels). A and B denote C1a and C1b domains, PH denotes the pleckstrin homology domain, and CAT denotes the kinase domain.