The Effect of Whole-Body Cryotherapy at Different Temperatures on Proinflammatory Cytokines, Oxidative Stress Parameters, and Disease Activity in Patients with Ankylosing Spondylitis
Table 2
Clinical characteristics of the studied group before and after the therapy.
Group () WBC −110°C with exercise therapy
Group () WBC −60°C with exercise therapy
Group () non-WBC with exercise therapy
Before
After
Before
After
Before
After
BASDAI
5.39 (1.12) (4.8; 4.6–6.5)
3.77 (1.56) (3.3; 2.6–5.1)
0.0001
5.48 (1.07) (5.5; 4.4–6.2)
3.7 (1.44) (3.2; 3.0–4.5)
0.0001
5.83 (1.29) (5.9; 4.6–6.8)
4.6 (1.72) (4.3; 3.7–5.6)
0.0007
0.4897 0.0790
ASDAS-CRP
3.17 (0.67) (3.24; 2.84–3.59)
2.66 (0.81) (2.70; 2.22–3.09)
0.0008
3.34 (0.85) (3.22; 2.69–3.94)
2.66 (0.7) (2.64; 2.26–3.03)
0.0001
3.34 (0.78) (3.38; 3.17–3.85)
2.95 (0.85) (2.88; 2.56–3.53)
0.0064
0.6467 0.4157
IL-17 (pg/m/L)
452.58 (58.76) (445.39; 397.73–486.60)
449.15 (70.30) (431.74; 397.73–486.6)
0.6378
457.83 (62.08) (445.39; 411.31–507.35)
449.34 (79.98) (424.92; 404.52–472.83)
0.3392
436.84 (50.65) (431.74; 404.52–459.09)
434.34 (58.73) (411.31; 397.73–459.09)
0.9108
0.5308 0.8118
IL-8 (pg/mL)
702.78 (705.62) () (413.49; 242.40–723.37)
139.1 (210.98) (29.16; 13.79–116.49)
0.0005
642.59 (625.31) () (500.87; 282.60–783.30)
130.26 (204.93) (37.41; 10.80–136.36)
0.0005
709.20 (724.07) (511.94; 169.47–1048.21)
42.31 (46.39) (29.19; 6.45–54.52)
0.0001
0.9917 0.3161
TAS (mM)
1.42 (1.37) () (1.43; 0.85–1.87)
1.50 (1.70) (1.02; 0.7–1.71)
0.5922
1.84 (1.18) (1.43; 1.15–2.55)
1.82 (1.5) (1.3; 0.82–2.29)
0.6894
1.47 (1.22) () (1.36; 0.73–2.24)
1.41 (0.82) (1.18; 0.87–2.11)
0.7938
0.6552 0.3860
TBARS (μM)
1.14 (0.42) (1.15; 0.79–1.42)
1.78 (0.75) (1.69; 1.3–2.43)
0.0002
1.41 (0.63) [] (1.33; 1.11–1.67)
1.61 (0.86) (1.46; 1.05–1.85)
0.0910
1.36 (0.43) () (1.4; 1.24–1.64)
1.54 (0.68) (1.52; 0.97–1.97)
0.3341
0.1472 0.3308
CRP (mg/L)
8.85 (13.34) (5.0; 2.8–7.5)
8.5 (11.48) (6.0; 3.52–8.66)
0.6951
10.75 (11.76) (7.02; 4.5–13.50)
9.67 (8.82) (7.5; 3.4–11.31)
0.5755
7.54 (5.64) (7.0; 4.0–10.2)
8.29 (8.29) (6.64; 4.5–8.99)
0.6009
0.3507 0.7222
The results are expressed as mean (SD) (median; interquartile range). is regarded as a statistically significant difference. BASDAI: Bath Ankylosing Spondylitis Disease Activity Index; ASDAS: Ankylosing Spondylitis Disease Activity Score; IL: interleukin; TAS: total antioxidant status; TBARS: thiobarbituric acid reactive substances; CRP: C-reactive protein; : adjusted number of subjects; WBC: whole-body cryotherapy.
