Ginkgo biloba Leaf Extract Protects against Myocardial Injury via Attenuation of Endoplasmic Reticulum Stress in Streptozotocin-Induced Diabetic ApoE^−/− Mice

Figure 8

Effects of GBE on ERS-related apoptosis hallmark expression. Expression levels of p-JNK/JNK, CHOP, caspase-12, and cleaved caspase-3 were determined by Western blotting. The expression levels of CHOP, caspase-12, and cleaved caspase-3, were adjusted for GAPDH, and the expression of p-JNK was adjusted for total JNK. These values were normalized over the untreated diabetic group. (a, b) Expression levels of p-JNK/JNK; (c, d) expression of CHOP; (e, f) expression of caspase-12; and (g, h) expression of cleaved caspase-3. and versus the untreated diabetic group. 1: control group; 2: untreated group; 3: atorvastatin group; 4: 200 mg/kg/day GBE group; and 5: 400 mg/kg/day GBE group.

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