Resveratrol Can Be Stable in a Medium Containing Fetal Bovine Serum with Pyruvate but Shortens the Lifespan of Human Fibroblastic Hs68 Cells

Table 1

Effect of SOD on Res degradation in DMEM with or without FBS.

	SOD activity (U/mL)
	0	0.5	5	50
Without FBS
Day 0	100 ± 2.6	100 ± 1.4	100 ± 5.7	100 ± 5.5
Day 1	76.0 ± 2.4	94.6 ± 2.1	97.6 ± 2.2	101.9 ± 1.6
Day 7	37.9 ± 1.5	67.4 ± 4.7	96.7 ± 0.9	99.5 ± 4.3
With FBS
Day 0	100 ± 2.0	100 ± 4.3	100 ± 2.6	100.0 ± 5.8
Day 1	95.6 ± 1.2	97.8 ± 3.1	101.3 ± 4.2	98.5 ± 1.8
Day 7	79.4 ± 1.4	89.6 ± 2.0	98.4 ± 3.7	97.1 ± 2.8

Res at 200 μM was incubated for 0–7 days in DMEM, which contained 3.7 g/L sodium bicarbonate with different doses of SOD with or without 10% FBS at 37°C in a CO₂ incubator supplied with 5% CO₂. The remaining Res (%) levels related to the peak area of Res on day 0 were determined by HPLC. Values (mean ± standard deviation; ) in the same column without a common letter are significantly different ().