Oxidative Stress Induces HSP90 Upregulation on the Surface of Primary Human Endothelial Cells: Role of the Antioxidant 7,8-Dihydroxy-4-methylcoumarin in Preventing HSP90 Exposure to the Immune System

<div>(a) Dose-dependent effect of H<sub>2</sub>O<sub>2</sub> on cellular HSP90 distribution in HUVEC. (b) Cellular HSP90 distribution in HUVEC pretreated with 7,8-dihydroxy-4-methylcoumarin (7,8-DHMC) or diluent alone as control and then exposed to 600 <i>μ</i>M of H<sub>2</sub>O<sub>2</sub> or left untreated. Images obtained by scanning confocal microscopy analysis were collected at 512 × 512 pixels. Green: HSP90 staining; blue: nucleus staining.</div>

Oxidative Medicine and Cellular Longevity

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Figure 4: Oxidative Stress Induces HSP90 Upregulation on the Surface of Primary Human Endothelial Cells: Role of the Antioxidant 7,8-Dihydroxy-4-methylcoumarin in Preventing HSP90 Exposure to the Immune System 

Figure 4 | Oxidative Stress Induces HSP90 Upregulation on the Surface of Primary Human Endothelial Cells: Role of the Antioxidant 7,8-Dihydroxy-4-methylcoumarin in Preventing HSP90 Exposure to the Immune System 