Indoleamine 2,3-Dioxygenase-Dependent Neurotoxic Kynurenine Metabolism Contributes to Poststroke Depression Induced in Mice by Ischemic Stroke along with Spatial Restraint Stress

Figure 6

Effect of aripiprazole on depressive-like behaviors and cognitive impairment in PSD mice. During 2 weeks of spatial restraint stress, the PSD mice were treated with either aripiprazole (1 mg/kg) or vehicle orally once per day. The body weight (a), sucrose preference test (b), and forced swim test (c) were performed at 5, 7, and 9 weeks after completing MCAO and spatial restraint stress; control, sham (PSD), and aripiprazole-treated group (PSD + APZ). In the Morris water maze test, representative swimming traces (d) and percent of time spent (e) in the target quadrant where the hidden platform was previously placed during the probe trial session at 10 weeks after completing MCAO and spatial restraint stress. Depressive behaviors and cognitive impairment in the PSD model were restored by aripiprazole treatment. Data are expressed as (). , , and vs. control; and vs. PSD.

(a)

(b)

(c)

(d)

(e)