Indoleamine 2,3-Dioxygenase-Dependent Neurotoxic Kynurenine Metabolism Contributes to Poststroke Depression Induced in Mice by Ischemic Stroke along with Spatial Restraint Stress

Figure 8

Effect of aripiprazole on IDO1 and HAAO expressions and QUIN production in the brain of PSD mice. IDO1 (a), HAAO (b), and QUIN (c) fluorescence intensities were determined by immunofluorescent staining of the nucleus accumbens (NAc), hippocampus (Hippo), and hypothalamus (Hypo) from control, sham (PSD), and aripiprazole-treated mice (PSD + APZ). Increased IDO1 and HAAO expression and QUIN production by PSD were reversed by aripiprazole treatment. Data are expressed as (). and vs. control; , and vs. PSD. (d) Representative images of immunofluorescent staining of QUIN in the nucleus accumbens (NAc) of control (Con), sham (PSD), and aripiprazole-treated mice (PSD + APZ). The yellow dashed rectangle marks the position of an enlarged image of QUIN. Nuclear DNA was labeled with blue fluorescence by DAPI. Scale .

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