Targeting Mitochondrial Bioenergetics as a Therapeutic Strategy for Chronic Lymphocytic Leukemia

Figure 2

Bioenergetics profile in normal B lymphocytes and primary CLL cells. General scheme of bioenergetics parameters during mitochondrial stress test is shown. Sequential injections of oligomycin, FCCP, rotenone, and antimycin A measure basal respiration (green), ATP-linked oxygen consumption (yellow), proton leak (pink), maximal respiration (orange), reserve respiratory capacity (gold: maximal respiration—basal respiration), and nonmitochondrial respiration (blue). Dashed lines indicate OCR for the portion of each defined parameter. CLL, chronic lymphocytic leukemia lymphocytes, (black line) and normal B-lymphocytes (red line). The comparison of mitochondrial of bioenergetics between CLL and normal B-lymphocytes shown in this figure is adapted based on the results demonstrated by Jitschin et al. [29].