Nephroprotective Effect of Zingerone against CCl₄-Induced Renal Toxicity in Swiss Albino Mice: Molecular Mechanism

Table 1

Effect of Zingerone on the activity of enzymatic antioxidants in the kidney tissue of Swiss albino mice treated with CCl₄.

Treatment	nmol NADPH oxidized/min/mg protein		GST (nmol CDNB conjugates formed/min/mg protein)	CAT (nmol H2O2 consumed/min/mg protein)	SOD (nmol (−) epinephrine protected from oxidation/min/mg protein)
	GPx	GR
G1 (NC)	46.36 ± 3.27	35.83 ± 2.14	0.66 ± 0.04	1.241 ± 0.07	1.97 ± 0.11
G2 (CCl4)	25.36 ± 1.56	19.87 ± 1.04	0.23 ± 0.02	0.71 ± 0.02	0.85 ± 0.05
G3 (CCl4 + Zingerone)	41.38 ± 1.36^∗∗	31.80 ± 1.80^∗	0.52 ± 0.04	1.07 ± 0.06	1.75 ± 0.14
G4 (Zingerone)	43.53 ± 2.12	33.91 ± 2.29	0.61 ± 0.05	1.12 ± 0.09	1.72 ± 0.18

versus group 1 (normal control). and versus group 2 (CCl₄ treated).