Research Article

Pretreatment with Shuanghe-Tang Extract Attenuates Postischemic Brain Injury and Edema in a Mouse Model of Stroke: An Analysis of Medicinal Herbs Listed in Dongui Bogam

Figure 6

Effects of Shuanghe-tang pretreatment on ZO-1 and occludin levels in ischemic mouse brains. Mice pretreated with Shuanghe-tang (300 mg/kg) exhibited increased expression of the tight junction proteins ZO-1 (b, c) and occludin (d, e) following focal cerebral ischemia. (a) Dashed yellow square indicates the photographed area. Representative photographs of ZO-1 ($) and occludin ($$). CD-31 staining for blood vessels is indicated in green. Scale bar = 50 μm. Quantification graphs of ZO-1 (c) and occludin (e) immunofluorescence ( each, , versus control group).
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