Epigenetic versus Genetic Deregulation of the KEAP1/NRF2 Axis in Solid Tumors: Focus on Methylation and Noncoding RNAs

Figure 2

Domain architecture of the NRF2 (a) and KEAP1 (b) proteins. (a) NRF2 protein is divided into seven highly conserved domains, Neh1 to Neh7 (NRF2-ECH homology: Neh). The coordinates of NRF2 protein domains are shown as follows: Neh2 (16-89aa); Neh2 DLG motif (17-32aa), Neh2 ETGE motif (77-82aa), Neh4 (111-134aa), Neh5 (182-209aa), Neh7 (209-316aa), Neh6 (337-394aa), Neh1 (435-568aa), and Neh3 (569-605aa). (b) KEAP1 protein contains a number of functional domains including the N-terminal region (NTR; 1-60aa), broad complex, tramtrack and bric-a-brac (BTB; 61-179aa), the intervening linker domain (IVR; 180-314aa), the double glycine/Kelch domain harboring six Kelch-repeat domains (315-359aa; 361-410aa; 412-457aa; 459-504aa; 506-551aa; 553-598aa), and the C-terminal region (CTR; 599-624aa).

(a)

(b)