The Encapsulation of Lycopene in Nanoliposomes Enhances Its Protective Potential in Methotrexate-Induced Kidney Injury Model

Table 3

Semiquantitative histopathological score analysis of renal tissue damage.

Histopathological lesion	C	NL	LYC	ENL	MTX	MTX-NL	MTX-LYC	MTX-ENL
Tubular changes
Tubular degeneration	—	—	—	—	+++	+++	++	+
Tubular cell edema/vacuolation	—	—	—	—	+++	+++	++	+
Tubular apoptosis/necrosis	—	—	—	—	++	++	+	—
Hyaline intratubular casts	—	—	—	—	++	++	+	—
Interstitial changes
Mononuclear cell infiltration	—	—	—	—	+++	+++	+	+
Interstitial swelling	—	—	—	—	+++	+++	++	+
Vascular congestion	—	—	—	—	+++	++	++	+
Glomerular changes
Glomerular degeneration	—	—	—	—	++	++	+	—

Scoring was done as follows: none (—), mild (+), moderate (++), and severe (+++).