Research Article
The Encapsulation of Lycopene in Nanoliposomes Enhances Its Protective Potential in Methotrexate-Induced Kidney Injury Model
Table 3
Semiquantitative histopathological score analysis of renal tissue damage.
| Histopathological lesion | C | NL | LYC | ENL | MTX | MTX-NL | MTX-LYC | MTX-ENL |
| Tubular changes | Tubular degeneration | — | — | — | — | +++ | +++ | ++ | + | Tubular cell edema/vacuolation | — | — | — | — | +++ | +++ | ++ | + | Tubular apoptosis/necrosis | — | — | — | — | ++ | ++ | + | — | Hyaline intratubular casts | — | — | — | — | ++ | ++ | + | — | Interstitial changes | Mononuclear cell infiltration | — | — | — | — | +++ | +++ | + | + | Interstitial swelling | — | — | — | — | +++ | +++ | ++ | + | Vascular congestion | — | — | — | — | +++ | ++ | ++ | + | Glomerular changes | Glomerular degeneration | — | — | — | — | ++ | ++ | + | — |
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Scoring was done as follows: none (—), mild (+), moderate (++), and severe (+++).
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