mTOR Inhibitor Therapy and Metabolic Consequences: Where Do We Stand?

Figure 1

mTOR signaling pathways. IRS 1/2: insulin receptor substrate protein-1/2; PI3K: phosphoinositide 3-kinase; AKT: protein kinase B; Grb 10: growth factor receptor-bound protein 10; AMPK: adenosine monophosphate-activated protein kinase; TSC1: tuberous sclerosis complex 1; TSC2: tuberous sclerosis complex 2; mTORC1: mTOR complex 1; mTORC2: mTOR complex 2; PDK: phosphoinositide-dependent protein kinase 1.