Hydrogen Sulfide Ameliorates Developmental Impairments of Rat Offspring with Prenatal Hyperhomocysteinemia
Table 1
The effects of NaHS treatment on the development of neurobehavioral reflexes of pups with prenatal hHCY.
Parameters
Control
Hcy
H2S
HcyH2S
Negative geotaxis (day of appearance)
6 (5–7)
6 (6–8)
6 (6–6)#
6 (5–7)#
Head shake reflex (number of the head rotations per min at Р8)
7 (5–11)
2 (1–4)
9 (4–14)#
4 (2–6),#
Righting reflex (day of appearance)
6 (4–7)
6 (6–8)
6 (3–6),#
4 (4–5),#
Righting reflex (time (s) at P6)
1 (1–2)
2 (2–4)
1 (1–0.75)#
1 (1–1.5)#
Cliff avoidance test (day of appearance)
6 (5–7)
7 (6–8)
6 (5–6)#
4 (4–4),#
Acoustic startle reflex (day of appearance)
10 (8–10)
10 (9–11)
8 (6–10),#
9 (8–12)#
Cliff avoidance caused by visual stimulus (day of appearance)
14 (12–15)
16 (16–17)
14 (13–16)#
14 (14–15)#
Free-fall righting (day of appearance)
12 (12–16)
19 (16–19)
14 (13–14)#
14 (13–14)#
Test olfactory discrimination (day of appearance)
14 (12–15)
16 (14–19)
14 (14–16)#
14 (13–15)#
Data are expressed as median (Q1–Q3). Statistical significance between medians was calculated using the nonparametric ANOVA Kruskal-Wallis test, Kolmogorov-Smirnov normality test, and Mann-Whitney. . compared to the control group, # compared to the Hcy group. : number of animals.
