Polydatin Protects Diabetic Heart against Ischemia-Reperfusion Injury via Notch1/Hes1-Mediated Activation of Pten/Akt Signaling

Figure 4

Effect of polydatin and DAPT on myocardial oxidative stress markers in MI/R-injured diabetic rats. The diabetic animals received MI/R operation in the presence or absence of polydatin or DAPT treatment. The measurement of oxidative stress markers was performed after 3 hours of reperfusion. (a) Bar diagram showing cardiac superoxide generation. (b) Bar diagram showing gp91^phox expression. Top images: representative blots. (c) Bar diagram showing myocardial malondialdehyde (MDA) contents. (d) Bar diagram showing myocardial superoxide dismutase (SOD) contents. The results are expressed as the mean ± SEM. samples per group. / versus the sham group, / versus the MI/R + V group, and / versus the MI/R + PD group. MI/R, myocardial ischemia-reperfusion; V, vehicle; PD, polydatin.

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