Polydatin Protects Diabetic Heart against Ischemia-Reperfusion Injury via Notch1/Hes1-Mediated Activation of Pten/Akt Signaling
Effect of LY294002 on myocardial oxidative/nitrative stress in MI/R-injured diabetic rats. The measurement was performed after 3 hours of reperfusion. (a) Bar diagram showing cardiac superoxide generation. (b) Bar diagram showing gp91phox expression. Top images: representative blots. (c) Bar diagram showing myocardial malondialdehyde (MDA) contents. (d) Bar diagram showing myocardial superoxide dismutase (SOD) contents. (e) Bar diagram showing Akt phosphorylation. Top images: representative blots. (f) Bar diagram showing iNOS expression. Top images: representative blots. (g) Bar diagram showing eNOS phosphorylation level. Top images: representative blots. (h) Bar diagram showing NO metabolites level. (i) Bar diagram showing nitrotyrosine intensity. (j) Representative myocardial immunohistochemistry images of nitrotyrosine (×200, bar = 200 μm). (k) Bar diagram showing myocardial nitrotyrosine content. The results are expressed as the mean ± SEM. samples per group. / versus the sham group and / versus the MI/R + PD group. MI/R, myocardial ischemia-reperfusion; PD, polydatin; LY, 294002.
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