Double Knockout of Peroxiredoxin 4 (Prdx4) and Superoxide Dismutase 1 (Sod1) in Mice Results in Severe Liver Failure

Figure 1

Body weight, plasma ALT, and AST activities in mice. (a) Representative plots of SOD1, Prdx4, Bip, cleaved caspase-3 (cleaved casp-3), and β-actin in whole liver lysates of mice with the indicated genotypes. (b) Body weight of mice with the indicated genotypes. Data are expressed as the . Number of mice: WT: , Sod1^−/−: , Prdx4^−/y: , and DKO: . versus WT mice. versus Prdx4^−/y mice. (c) Plasma ALT activities in mice with the indicated genotypes. Data are expressed as the . Number of mice: WT: , Sod1^−/−: , Prdx4^−/y: , and DKO: . versus WT mice. versus Prdx4^−/y mice. (d) Plasma AST activities in mice with the indicated genotypes. Data are expressed as the . Number of mice: WT: , Sod1^−/−: , Prdx4^−/y: , and DKO: . versus WT mice. versus Sod1^−/− mice. versus Prdx4^−/y mice.

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