Double Knockout of Peroxiredoxin 4 (Prdx4) and Superoxide Dismutase 1 (Sod1) in Mice Results in Severe Liver Failure

Figure 2

Histological analysis of the liver pathology in DKO mice. (a) Representative images of hematoxylin and eosin- (H&E) stained livers from the indicated genotypes. Inset: high-magnification images of corresponding liver sections. Note that there were degenerative changes, as evidenced by the ballooning of hepatocytes in livers of DKO mice. Scale bars: 50 μm. (b) Immunohistochemical staining of cleaved caspase-3 in livers with the indicated genotypes. Nuclei were stained with hematoxylin. Scale bars: 50 μm.

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