Double Knockout of Peroxiredoxin 4 (Prdx4) and Superoxide Dismutase 1 (Sod1) in Mice Results in Severe Liver Failure

Figure 3

Lipid accumulation in livers of DKO mice. (a) Representative images of Oil Red O-stained livers with the indicated genotypes. Scale bars: 50 μm. (b) Plasma TG levels in mice with the indicated genotypes. Data are expressed as the . Number of mice: WT: , Sod1^−/−: , Prdx4^−/y: , and DKO: . versus WT mice. (c) Plasma NEFA levels in mice with the indicated genotypes. Data are expressed as the . Number of mice: WT: , Sod1^−/−: , Prdx4^−/y: , and DKO: . versus WT mice. (d) VLDL-TG secretion in mice. Plasma TG levels were measured before and 180 min after intravenous tyloxapol injection. TG secretion rate during the 180 min experiment was calculated. Data are expressed as the (). versus WT mice. versus Prdx4^−/y mice. (e) Plasma TG levels were measured at 60 min intervals after the oral administration of olive oil. Data are expressed as (). No difference was observed between the different genotypes.

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