Long-Term Exercise Protects against Cellular Stresses in Aged Mice
Table 1
Effect of aging and long-term voluntary wheel-running on the levels of 4-hydroxynonenal adducts (4-HNE), lipid hydroperoxides (LPO), protein carbonyls, and heat shock proteins in T.A. and soleus mice muscles.
Levels of 4-HNE adducts, LPO, protein carbonyls, and heat shock proteins
Y
OS
OE
T.A.
4-HNE
1.00 ± 0.04
0.88 ± 0.11
0.54 ± 0.013#
LPO
1.00 ± 0.01
1.21 ± 0.01
1.26 ± 0.02
Protein carbonyls
1.00 ± 0.01
1.02 ± 0.01
1.04 ± 0.01
HSP25
1.00 ± 0.08
1.14 ± 0.23
1.14 ± 0.10
HSP60
1.00 ± 0.05
1.05 ± 0.12
1.28 ± 0.11
HSP90
1.00 ± 0.10
1.38 ± 0.24
1.14 ± 0.07
Soleus
4-HNE
1.00 ± 0.13
0.76 ± 0.18
1.07 ± 0.16
LPO
1.00
0.94
0.95
Protein carbonyls
1.00 ± 0.01
1.01 ± 0.01
1.01 ± 0.01
HSP25
1.00 ± 0.06
1.08 ± 0.54
1.55 ± 0.19
HSP60
1.00 ± 0.07
0.71 ± 0.07
0.72 ± 0.05
HSP90
1.00 ± 0.07
0.89 ± 0.42
1.19 ± 0.13
Data are mean ± SEM. Groups are as follows: Y, young 3-month-old mice; OS, sedentary 24-month-old mice; OE, 24-month-old mice after 21 months of voluntary wheel-running. for Y, for OS, and for OE. Difference due to exercise: .
