NLRP3 Inflammasome Formation and Activation in Nonalcoholic Steatohepatitis: Therapeutic Target for Antimetabolic Syndrome Remedy FTZ

Figure 3

Fibrogenic phenotypes in the liver from mice on the HFD with and without FTZ treatment. (a) Representative immunohistochemical images showing enhanced α-SMA and vimentin staining, which are the markers of phenotype changed from quiescent to activated in HSCs. FTZ reduced HFD-induced increase in α-SMA and vimentin staining. (b) Summarized data depicting a significant increase in α-SMA and vimentin level in the liver of mice on the HFD with and without FTZ treatment ( mice per group). (c, d) Representative images and PPC showing FLICA, active caspase-1 colocalization with α-SMA or vimentin staining in the liver of mice on the HFD, which was reduced by FTZ ( mice per group). versus ND-Vehl group; versus HFD-Vehl group.

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