[Retracted] The Protective Role of Brain CYP2J in Parkinson’s Disease Models

Figure 3

The effects of CYP2J transfection on the loss of dopaminergic (DA) neurons in the SN and behavioral impairment in the LPS PD animal model. Fluorescent immunocytochemistry data shows the accumulation of α-synuclein (blue) in tyrosine hydroxylase positive neurons (red) after LPS treatment for 12 and 21 days (a); however, CYP2J transfection attenuated the LPS-induced accumulation of α-synuclein. Immunohistochemistry staining shows the loss of DA neurons in the SN after LPS treatment (b). There were an increased number of DA neurons remaining in the SNpc of rats transfected with the CYP2J3 expression vector compared with the LPS group (c). Compared with LPS-treated rats, the number of rotations by rats with high CYP2J3 levels was decreased on day 12 (d) and day 21 (e) after LPS treatment. Data were analyzed by one-way ANOVA. The data are ; , compared with respective controls.

(a)

(b)

(c)

(d)

(e)