Research Article

[Retracted] The Protective Role of Brain CYP2J in Parkinson’s Disease Models

Figure 6

Changes in genes related to mitochondrial oxidative defenses in the 6-OHDA PD animal model. Fluorescent immunocytochemistry data shows reduced levels of Nrf2 (blue) and CYP2J3 (red) protein in rats treated with 6-OHDA for 12 and 21 days (a). Nrf2 protein levels were increased following transfection with the CYP2J3 expression vector (b). Compared with the control, mRNA levels of CREB and CYP2J3 were decreased by 6-OHDA treatment (c). The inhibition of Nrf2, SOD1, CAT, and GPX1 mRNA levels following 6-OHDA treatment was attenuated by transfection with CYP2J3, compared with the 6-OHDA group (d). Data were analyzed by one-way ANOVA. The data are ; , , , and compared with respective controls.