Physicochemical Characterization, Microbiological Quality and Safety, and Pharmacological Potential of Hancornia speciosa Gomes

Table 4

Acetylcholinesterase- (AChE-), butyrylcholinesterase- (BChE-), tyrosinase-, hyaluronidase-, pancreatic lipase-, α-amylase-, and α-glucosidase-inhibiting activities of the ethanolic extract from Hancornia speciosa leaves (EEHS), rutin (Rut), catechin (Cat), and isoquercetin (Isoq).

	AChE	BchE	Tyrosinase	Hyaluronidase	Pancreatic lipase	α-Amylase	α-Glucosidase
	IC50 (μg/mL)	IC50 (μg/mL)	IC50 (μg/mL)	% (μg/mL)	IC50 (μg/mL)	IC50 (μg/mL)	IC50 (μg/mL)
EEHS	257.2 ± 10.8	190.3 ± 9.8	159.4 ± 2.4	22.5 ± 1.6	3.3 ± 0.3	35.8 ± 2.9	31.6 ± 1.5
Rut	437.6 ± 9.9	272.9 ± 8.8	583.2 ± 12.9	12.3 ± 0.9	17.2 ± 0.9	77.9 ± 0.6	74.9 ± 2.3
Cat	379.0 ± 8.4	312.6 ± 6.7	679.2 ± 11.8	12.3 ± 0.8	24.5 ± 0.6	50.3 ± 2.6	68.4 ± 1.6
Isoq	527.8 ± 12.1	342.8 ± 7.6	610.7 ± 7.1	8.8 ± 0.8	26.7 ± 1.6	73.2 ± 1.5	54.9 ± 2.3
Eserine	0.005 ± 0.001	0.037 ± 0.003	—	—	—	—	—
Kojic ac.	—	—	6.5 ± 0.5	—	—	—	—
EGC	—	—	—	97.9 ± 0.8	—	—	—
Orlistat	—	—	—	—	0.016 ± 0.02	—	—
Acarbose	—	—	—	—	—	67.5 ± 1.5	49.7 ± 2.1

Values are expressed as the mean (μg/mL), IC₅₀, and percentage ± SEM of experiments performed in triplicate. when comparing the treatment groups with the acarbose control groups, epigallocatechin (EGC). compared with the catechin group versus the rutin, isoquercetin, and control groups (acarbose). compared with the EEHS group versus the rutin, catechin, isoquercetin, and control groups (eserine, kojic acid, ECG: epigallocatechin, orlistat, or acarbose).