Genomic Approach to Understand the Association of DNA Repair with Longevity and Healthy Aging Using Genomic Databases of Oldest-Old Population

Table 1

Summary of DNA repair-associated genes with significant genomic variants in longevity.

Genes	Variations	Region	Populations	References
ATM	rs189037	5-UTR	Chinese (Han)	[132]
			Italian	[133]
ATRIP	rs9876781	Upstream	American (Caucasian)	[134]
EGFR	rs2072454	Exon (synonymous)	Korean	[135]
	rs2293347	Exon (synonymous)
	rs3807362	3-UTR
	rs884225	3-UTR
ERCC2	Lys751Gln^§	Missense (stop-gain)	Polish	[136]
EXO1	rs1776180	Upstream	German	[137]
	rs735943	Exon (missense; H/R)
	rs4149965	Exon (missense; V/M or V/L)
HSPA1A	−110A/C	Upstream	Italian (Southern)	[138]
			Danish	[139–141]
	G190C		Chinese (Uighur in Xinjiang)	[142]
HSPA1B	A1267G		Danish	[141]
			Chinese (Uighur in Xinjiang)	[142]
HSPA1L	T2437C		Danish	[141]
			Chinese (Uighur in Xinjiang)	[142]
MLH1	C670, A676, T1172		Korean	[143]
	rs13320360	Intron	Danish	[119]
POLB	rs2953983	Intron	Danish	[119]
RAD23B	rs1805329	Exon (missense; A/V)	Danish	[119]
RAD52	rs11571461	Intron	Danish	[119]
SIRT1	rs3758391	Upstream	Chinese (Han)	[144]
	rs4746720	3-UTR
	rs7896005	Intron	American (Caucasian)	[145]
	rs12778366	Upstream	Dutch	[146]
TP53	rs1042522	Exon (missense; P/R or P/H)	Danish	[127]
			Italian (Central)	[128]
	rs9616906	Upstream	American (Caucasian)	[134]
WRN	rs13251813	Intron	Danish	[119]
XRCC5	rs705649	Intron	Danish	[119]

Variation in amino acid; studies on haplotype analysis.