Oxidative Medicine and Cellular Longevity

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1. I. J. Wallace, S. Worthington, D. T. Felson et al., “Knee osteoarthritis has doubled in prevalence since the mid-20th century,” Proceedings of the National Academy of Sciences of the United States of America, vol. 114, no. 35, pp. 9332–9336, 2017. View at Publisher · View at Google Scholar
2. S. Miyaki and H. Asahara, “Macro view of microRNA function in osteoarthritis,” Nature Reviews Rheumatology, vol. 8, no. 9, pp. 543–552, 2012. View at Publisher · View at Google Scholar · View at Scopus
3. M. C. Haigis and B. A. Yankner, “The aging stress response,” Molecular Cell, vol. 40, no. 2, pp. 333–344, 2010. View at Publisher · View at Google Scholar · View at Scopus
4. C. Franceschi, P. Garagnani, G. Vitale, M. Capri, and S. Salvioli, “Inflammaging and ‘Garb-aging’,” Trends in Endocrinology and Metabolism, vol. 28, no. 3, pp. 199–212, 2017. View at Publisher · View at Google Scholar · View at Scopus
5. L. Lourido, B. Ayoglu, J. Fernandez-Tajes et al., “Discovery of circulating proteins associated to knee radiographic osteoarthritis,” Scientific Reports, vol. 7, no. 1, p. 137, 2017. View at Publisher · View at Google Scholar
6. S. S. Glasson, T. J. Blanchet, and E. A. Morris, “The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse,” Osteoarthritis and Cartilage, vol. 15, no. 9, pp. 1061–1069, 2007. View at Publisher · View at Google Scholar · View at Scopus
7. S. S. Glasson, “In vivo osteoarthritis target validation utilizing genetically-modified mice,” Current Drug Targets, vol. 8, no. 2, pp. 367–376, 2007. View at Publisher · View at Google Scholar · View at Scopus
8. L. Wu, X. Huang, L. Li, H. Huang, R. Xu, and W. Luyten, “Insights on biology and pathology of HIF-1α/-2α, TGFβ/BMP, Wnt/β-catenin, and NF-κB pathways in osteoarthritis,” Current Pharmaceutical Design, vol. 18, no. 22, pp. 3293–3312, 2012. View at Publisher · View at Google Scholar
9. P. Wojdasiewicz, L. A. Poniatowski, and D. Szukiewicz, “The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis,” Mediators of Inflammation, vol. 2014, Article ID 561459, 19 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
10. P. M. van der Kraan and W. B. van den Berg, “Osteoarthritis in the context of ageing and evolution. Loss of chondrocyte differentiation block during ageing,” Ageing Research Reviews, vol. 7, no. 2, pp. 106–113, 2008. View at Publisher · View at Google Scholar · View at Scopus
11. T. Aigner and N. Gerwin, “Growth plate cartilage as developmental model in osteoarthritis research--potentials and limitations,” Current Drug Targets, vol. 8, no. 2, pp. 377–385, 2007. View at Publisher · View at Google Scholar · View at Scopus
12. L. J. Sandell and T. Aigner, “Articular cartilage and changes in arthritis. An introduction: cell biology of osteoarthritis,” Arthritis Research, vol. 3, no. 2, pp. 107–113, 2001. View at Publisher · View at Google Scholar · View at Scopus
13. E. Croco, S. Marchionni, G. Storci et al., “Convergent adaptation of cellular machineries in the evolution of large body masses and long life spans,” Biogerontology, vol. 18, no. 4, pp. 485–497, 2017. View at Publisher · View at Google Scholar · View at Scopus
14. E. Croco, S. Marchionni, M. Bocchini et al., “DNA damage detection by 53BP1: relationship to species longevity,” The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, vol. 72, no. 6, pp. glw170–glw770, 2016. View at Publisher · View at Google Scholar · View at Scopus
15. E. Croco, S. Marchionni, and A. Lorenzini, “Genetic instability and aging under the scrutiny of comparative biology: a meta-analysis of spontaneous micronuclei frequency,” Mechanisms of Ageing and Development, vol. 156, pp. 34–41, 2016. View at Publisher · View at Google Scholar · View at Scopus
16. A. Lorenzini, F. B. Johnson, A. Oliver et al., “Significant correlation of species longevity with DNA double strand break recognition but not with telomere length,” Mechanisms of Ageing and Development, vol. 130, no. 11-12, pp. 784–792, 2009. View at Publisher · View at Google Scholar · View at Scopus
17. K. B. Marcu, M. Otero, E. Olivotto, R. M. Borzi, and M. B. Goldring, “NF-κB signaling: multiple angles to target OA,” Current Drug Targets, vol. 11, no. 5, pp. 599–613, 2010. View at Publisher · View at Google Scholar · View at Scopus
18. E. Olivotto, R. M. Borzi, R. Vitellozzi et al., “Differential requirements for IKKα and IKKβ in the differentiation of primary human osteoarthritic chondrocytes,” Arthritis & Rheumatism, vol. 58, no. 1, pp. 227–239, 2008. View at Publisher · View at Google Scholar · View at Scopus
19. M. Adli, E. Merkhofer, P. Cogswell, and A. S. Baldwin, “IKKα and IKKβ each function to regulate NF-κB activation in the TNF-induced/canonical pathway,” PLoS One, vol. 5, no. 2, article e9428, 2010. View at Publisher · View at Google Scholar · View at Scopus
20. N. D. Perkins, “Integrating cell-signalling pathways with NF-κB and IKK function,” Nature Reviews. Molecular Cell Biology, vol. 8, no. 1, pp. 49–62, 2007. View at Publisher · View at Google Scholar · View at Scopus
21. S. Saccani, S. Pantano, and G. Natoli, “p38-Dependent marking of inflammatory genes for increased NF-κB recruitment,” Nature Immunology, vol. 3, no. 1, pp. 69–75, 2001. View at Publisher · View at Google Scholar · View at Scopus
22. M. B. Goldring, M. Otero, D. A. Plumb et al., “Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis,” European Cells & Materials, vol. 21, pp. 202–220, 2011. View at Publisher · View at Google Scholar
23. E. Olivotto, M. Otero, A. Astolfi et al., “IKKα/CHUK regulates extracellular matrix remodeling independent of its kinase activity to facilitate articular chondrocyte differentiation,” PLoS One, vol. 8, no. 9, article e73024, 2013. View at Publisher · View at Google Scholar
24. F. Veronesi, G. Giavaresi, M. Maglio et al., “Chondroprotective activity of N-acetyl phenylalanine glucosamine derivative on knee joint structure and inflammation in a murine model of osteoarthritis,” Osteoarthritis and Cartilage, vol. 25, no. 4, pp. 589–599, 2017. View at Publisher · View at Google Scholar · View at Scopus
25. T. Yamaguchi, Y. Miki, and K. Yoshida, “Protein kinase C δ activates IκB-kinase α to induce the p53 tumor suppressor in response to oxidative stress,” Cellular Signalling, vol. 19, no. 10, pp. 2088–2097, 2007. View at Publisher · View at Google Scholar · View at Scopus
26. S. K. Biswas, “Does the interdependence between oxidative stress and inflammation explain the antioxidant paradox?” Oxidative Medicine and Cellular Longevity, vol. 2016, Article ID 5698931, 9 pages, 2016. View at Publisher · View at Google Scholar · View at Scopus
27. E. S. Helton and X. Chen, “p53 modulation of the DNA damage response,” Journal of Cellular Biochemistry, vol. 100, no. 4, pp. 883–896, 2007. View at Publisher · View at Google Scholar · View at Scopus
28. X. Zhu, S. Yang, W. Lin et al., “Roles of cell cycle regulators cyclin D1, CDK4, and p53 in knee osteoarthritis,” Genetic Testing and Molecular Biomarkers, vol. 20, no. 9, pp. 529–534, 2016. View at Publisher · View at Google Scholar · View at Scopus
29. S. Guidotti, M. Minguzzi, D. Platano et al., “Lithium chloride dependent glycogen synthase kinase 3 inactivation links oxidative DNA damage, hypertrophy and senescence in human articular chondrocytes and reproduces chondrocyte phenotype of obese osteoarthritis patients,” PLoS One, vol. 10, no. 11, article e0143865, 2015. View at Publisher · View at Google Scholar · View at Scopus
30. J. Rose, S. Soder, C. Skhirtladze et al., “DNA damage, discoordinated gene expression and cellular senescence in osteoarthritic chondrocytes,” Osteoarthritis and Cartilage, vol. 20, no. 9, pp. 1020–1028, 2012. View at Publisher · View at Google Scholar · View at Scopus
31. Q. Zhuo, W. Yang, J. Chen, and Y. Wang, “Metabolic syndrome meets osteoarthritis,” Nature Reviews Rheumatology, vol. 8, no. 12, pp. 729–737, 2012. View at Publisher · View at Google Scholar · View at Scopus
32. M. Roldan, M. Macias-Gonzalez, R. Garcia, F. J. Tinahones, and M. Martin, “Obesity short-circuits stemness gene network in human adipose multipotent stem cells,” The FASEB Journal, vol. 25, no. 12, pp. 4111–4126, 2011. View at Publisher · View at Google Scholar · View at Scopus
33. D. S. Karolina, S. Tavintharan, A. Armugam et al., “Circulating miRNA profiles in patients with metabolic syndrome,” The Journal of Clinical Endocrinology and Metabolism, vol. 97, no. 12, pp. E2271–E2276, 2012. View at Publisher · View at Google Scholar · View at Scopus
34. A. Salminen, J. M. Hyttinen, and K. Kaarniranta, “AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan,” Journal of Molecular Medicine, vol. 89, no. 7, pp. 667–676, 2011. View at Publisher · View at Google Scholar · View at Scopus
35. H. Fahmi, J. Martel-Pelletier, J. P. Pelletier, and M. Kapoor, “Peroxisome proliferator-activated receptor gamma in osteoarthritis,” Modern Rheumatology, vol. 21, no. 1, pp. 1–9, 2014. View at Publisher · View at Google Scholar
36. R. Terkeltaub, B. Yang, M. Lotz, and R. Liu-Bryan, “Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1β and tumor necrosis factor α,” Arthritis and Rheumatism, vol. 63, no. 7, pp. 1928–1937, 2011. View at Publisher · View at Google Scholar · View at Scopus
37. H. Afif, M. Benderdour, L. Mfuna-Endam et al., “Peroxisome proliferator-activated receptor γ1 expression is diminished in human osteoarthritic cartilage and is downregulated by interleukin-1β in articular chondrocytes,” Arthritis Research & Therapy, vol. 9, no. 2, p. R31, 2007. View at Publisher · View at Google Scholar · View at Scopus
38. Y. Figenschau, G. Knutsen, S. Shahazeydi, O. Johansen, and B. Sveinbjornsson, “Human articular chondrocytes express functional leptin receptors,” Biochemical and Biophysical Research Communications, vol. 287, no. 1, pp. 190–197, 2001. View at Publisher · View at Google Scholar · View at Scopus
39. O. P. Stannus, Y. Cao, B. Antony et al., “Cross-sectional and longitudinal associations between circulating leptin and knee cartilage thickness in older adults,” Annals of the Rheumatic Diseases, vol. 74, no. 1, pp. 82–88, 2014. View at Publisher · View at Google Scholar · View at Scopus
40. M. Scotece and A. Mobasheri, “Leptin in osteoarthritis: focus on articular cartilage and chondrocytes,” Life Sciences, vol. 140, pp. 75–78, 2015. View at Publisher · View at Google Scholar · View at Scopus
41. M. Sowers, C. A. Karvonen-Gutierrez, R. Palmieri-Smith, J. A. Jacobson, Y. Jiang, and J. A. Ashton-Miller, “Knee osteoarthritis in obese women with cardiometabolic clustering,” Arthritis and Rheumatism, vol. 61, no. 10, pp. 1328–1336, 2009. View at Publisher · View at Google Scholar · View at Scopus
42. P. Lepetsos and A. G. Papavassiliou, “ROS/oxidative stress signaling in osteoarthritis,” Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol. 1862, no. 4, pp. 576–591, 2016. View at Publisher · View at Google Scholar · View at Scopus
43. S. Cetrullo, S. D'Adamo, B. Tantini, R. M. Borzi, and F. Flamigni, “mTOR, AMPK, and Sirt1: key players in metabolic stress management,” Critical Reviews in Eukaryotic Gene Expression, vol. 25, no. 1, pp. 59–75, 2015. View at Publisher · View at Google Scholar
44. C. L. Shen, B. J. Smith, D. F. Lo et al., “Dietary polyphenols and mechanisms of osteoarthritis,” The Journal of Nutritional Biochemistry, vol. 23, no. 11, pp. 1367–1377, 2012. View at Publisher · View at Google Scholar · View at Scopus
45. C. Arias, T. Zambrano, D. S. Abdalla, and L. A. Salazar, “Polyphenol-related epigenetic modifications in osteoarthritis: current therapeutic perspectives,” Current Pharmaceutical Design, vol. 22, no. 44, pp. 6682–6693, 2017. View at Publisher · View at Google Scholar · View at Scopus
46. S. D'Adamo, S. Cetrullo, S. Guidotti, R. M. Borzi, and F. Flamigni, “Hydroxytyrosol modulates the levels of microRNA-9 and its target sirtuin-1 thereby counteracting oxidative stress-induced chondrocyte death,” Osteoarthritis and Cartilage, vol. 25, no. 4, pp. 600–610, 2017. View at Publisher · View at Google Scholar · View at Scopus
47. S. Cetrullo, S. D'Adamo, S. Guidotti, R. M. Borzi, and F. Flamigni, “Hydroxytyrosol prevents chondrocyte death under oxidative stress by inducing autophagy through sirtuin 1-dependent and -independent mechanisms,” Biochimica et Biophysica Acta (BBA) - General Subjects, vol. 1860, no. 6, pp. 1181–1191, 2016. View at Publisher · View at Google Scholar · View at Scopus
48. F. Berenbaum, T. M. Griffin, and R. Liu-Bryan, “Review: metabolic regulation of inflammation in osteoarthritis,” Arthritis & Rheumatology, vol. 69, no. 1, pp. 9–21, 2017. View at Publisher · View at Google Scholar · View at Scopus
49. B. Lu, J. B. Driban, C. Xu, K. L. Lapane, T. E. McAlindon, and C. B. Eaton, “Dietary fat intake and radiographic progression of knee osteoarthritis: data from the osteoarthritis initiative,” Arthritis Care & Research, vol. 69, no. 3, pp. 368–375, 2017. View at Publisher · View at Google Scholar · View at Scopus
50. K. T. Sibille, C. King, T. J. Garrett et al., “Omega-6: Omega-3 PUFA Ratio, Pain, Functioning, and Distress in Adults with Knee Pain,” The Clinical Journal of Pain, p. 1, 2017. View at Publisher · View at Google Scholar · View at Scopus
51. N. S. Kalupahana, K. J. Claycombe, and N. Moustaid-Moussa, “(n-3) fatty acids alleviate adipose tissue inflammation and insulin resistance: mechanistic insights,” Advances in Nutrition, vol. 2, no. 4, pp. 304–316, 2011. View at Publisher · View at Google Scholar · View at Scopus
52. D. Medina-Luna, M. G. Santamaria-Olmedo, Y. Zamudio-Cuevas et al., “Hyperlipidemic microenvironment conditionates damage mechanisms in human chondrocytes by oxidative stress,” Lipids in Health and Disease, vol. 16, no. 1, p. 114, 2017. View at Publisher · View at Google Scholar
53. S. Sekar, S. R. Shafie, I. Prasadam et al., “Saturated fatty acids induce development of both metabolic syndrome and osteoarthritis in rats,” Scientific Reports, vol. 7, article 46457, 2017. View at Publisher · View at Google Scholar · View at Scopus
54. O. Alvarez-Garcia, N. H. Rogers, R. G. Smith, and M. K. Lotz, “Palmitate has proapoptotic and proinflammatory effects on articular cartilage and synergizes with interleukin-1,” Arthritis & Rheumatology, vol. 66, no. 7, pp. 1779–1788, 2014. View at Publisher · View at Google Scholar · View at Scopus
55. S. Farnaghi, I. Prasadam, G. Cai et al., “Protective effects of mitochondria-targeted antioxidants and statins on cholesterol-induced osteoarthritis,” The FASEB Journal, vol. 31, no. 1, pp. 356–367, 2016. View at Publisher · View at Google Scholar · View at Scopus
56. F. Kostopoulou, K. N. Malizos, I. Papathanasiou, and A. Tsezou, “MicroRNA-33a regulates cholesterol synthesis and cholesterol efflux-related genes in osteoarthritic chondrocytes,” Arthritis Research & Therapy, vol. 17, no. 1, p. 42, 2015. View at Publisher · View at Google Scholar · View at Scopus
57. F. Kostopoulou, V. Gkretsi, K. N. Malizos et al., “Central role of SREBP-2 in the pathogenesis of osteoarthritis,” PLoS One, vol. 7, no. 5, article e35753, 2012. View at Publisher · View at Google Scholar · View at Scopus
58. C. Vaamonde-Garcia, A. Courties, A. Pigenet et al., “The nuclear factor-erythroid 2-related factor/heme oxygenase-1 axis is critical for the inflammatory features of type 2 diabetes-associated osteoarthritis,” The Journal of Biological Chemistry, vol. 292, no. 35, pp. 14505–14515, 2017. View at Publisher · View at Google Scholar
59. K. B. King and A. K. Rosenthal, “The adverse effects of diabetes on osteoarthritis: update on clinical evidence and molecular mechanisms,” Osteoarthritis and Cartilage, vol. 23, no. 6, pp. 841–850, 2015. View at Publisher · View at Google Scholar · View at Scopus
60. A. Mobasheri, M. P. Rayman, O. Gualillo, J. Sellam, P. van der Kraan, and U. Fearon, “The role of metabolism in the pathogenesis of osteoarthritis,” Nature Reviews Rheumatology, vol. 13, no. 5, pp. 302–311, 2017. View at Publisher · View at Google Scholar · View at Scopus
61. Y. J. Chen, D. C. Chan, K. C. Lan et al., “PPARγ is involved in the hyperglycemia-induced inflammatory responses and collagen degradation in human chondrocytes and diabetic mouse cartilages,” Journal of Orthopaedic Research, vol. 33, no. 3, pp. 373–381, 2015. View at Publisher · View at Google Scholar · View at Scopus
62. R. Liu-Bryan and R. Terkeltaub, “Emerging regulators of the inflammatory process in osteoarthritis,” Nature Reviews Rheumatology, vol. 11, no. 1, pp. 35–44, 2014. View at Publisher · View at Google Scholar · View at Scopus
63. J. Labbadia and R. I. Morimoto, “The biology of proteostasis in aging and disease,” Annual Review of Biochemistry, vol. 84, no. 1, pp. 435–464, 2015. View at Publisher · View at Google Scholar · View at Scopus
64. F. U. Hartl, A. Bracher, and M. Hayer-Hartl, “Molecular chaperones in protein folding and proteostasis,” Nature, vol. 475, no. 7356, pp. 324–332, 2011. View at Publisher · View at Google Scholar · View at Scopus
65. J. Labbadia and R. I. Morimoto, “Repression of the heat shock response is a programmed event at the onset of reproduction,” Molecular Cell, vol. 59, no. 4, pp. 639–650, 2015. View at Publisher · View at Google Scholar · View at Scopus
66. H. E. Gruber, G. L. Hoelscher, J. A. Ingram, N. Zinchenko, and E. N. Hanley Jr, “Senescent vs. non-senescent cells in the human annulus in vivo: cell harvest with laser capture microdissection and gene expression studies with microarray analysis,” BMC Biotechnology, vol. 10, no. 1, p. 5, 2010. View at Publisher · View at Google Scholar · View at Scopus
67. S. D. Westerheide, J. Anckar, S. M. Stevens Jr., L. Sistonen, and R. I. Morimoto, “Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1,” Science, vol. 323, no. 5917, pp. 1063–1066, 2009. View at Publisher · View at Google Scholar · View at Scopus
68. S. J. Park, O. Gavrilova, A. L. Brown et al., “DNA-PK promotes the mitochondrial, metabolic, and physical decline that occurs during aging,” Cell Metabolism, vol. 25, no. 5, pp. 1135–1146.e7, 2017. View at Publisher · View at Google Scholar · View at Scopus
69. G. Schett, K. Redlich, Q. Xu et al., “Enhanced expression of heat shock protein 70 (hsp70) and heat shock factor 1 (HSF1) activation in rheumatoid arthritis synovial tissue. Differential regulation of hsp70 expression and hsf1 activation in synovial fibroblasts by proinflammatory cytokines, shear stress, and antiinflammatory drugs,” The Journal of Clinical Investigation, vol. 102, no. 2, pp. 302–311, 1998. View at Publisher · View at Google Scholar
70. S. Etienne, N. Gaborit, C. Henrionnet et al., “Local induction of heat shock protein 70 (Hsp70) by proteasome inhibition confers chondroprotection during surgically induced osteoarthritis in the rat knee,” Bio-medical Materials and Engineering, vol. 18, no. 4-5, pp. 253–260, 2008. View at Publisher · View at Google Scholar · View at Scopus
71. M. Siebelt, H. Jahr, H. C. Groen et al., “Hsp90 inhibition protects against biomechanically induced osteoarthritis in rats,” Arthritis and Rheumatism, vol. 65, no. 8, pp. 2102–2112, 2013. View at Publisher · View at Google Scholar · View at Scopus
72. J. Y. Ko, Y. C. Sun, W. C. Li, and F. S. Wang, “Chaperonin 60 regulation of SOX9 ubiquitination mitigates the development of knee osteoarthritis,” Journal of Molecular Medicine, vol. 94, no. 7, pp. 755–769, 2016. View at Publisher · View at Google Scholar · View at Scopus
73. C. Ruiz-Romero, V. Calamia, J. Mateos et al., “Mitochondrial dysregulation of osteoarthritic human articular chondrocytes analyzed by proteomics: a decrease in mitochondrial superoxide dismutase points to a redox imbalance,” Molecular & Cellular Proteomics, vol. 8, no. 1, pp. 172–189, 2009. View at Publisher · View at Google Scholar · View at Scopus
74. S. Lambrecht, G. Verbruggen, D. Elewaut, and D. Deforce, “Differential expression of αB-crystallin and evidence of its role as a mediator of matrix gene expression in osteoarthritis,” Arthritis and Rheumatism, vol. 60, no. 1, pp. 179–188, 2009. View at Publisher · View at Google Scholar · View at Scopus
75. S. Lambrecht, M. Dhaenens, F. Almqvist et al., “Proteome characterization of human articular chondrocytes leads to novel insights in the function of small heat-shock proteins in chondrocyte homeostasis,” Osteoarthritis and Cartilage, vol. 18, no. 3, pp. 440–446, 2010. View at Publisher · View at Google Scholar · View at Scopus
76. O. Gabay, H. Oppenhiemer, H. Meir, K. Zaal, C. Sanchez, and M. Dvir-Ginzberg, “Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice,” Annals of the Rheumatic Diseases, vol. 71, no. 4, pp. 613–616, 2012. View at Publisher · View at Google Scholar · View at Scopus
77. O. Gabay, C. Sanchez, M. Dvir-Ginzberg et al., “Sirtuin 1 enzymatic activity is required for cartilage homeostasis in vivo in a mouse model,” Arthritis and Rheumatism, vol. 65, no. 1, pp. 159–166, 2013. View at Publisher · View at Google Scholar · View at Scopus
78. O. Gabay, K. J. Zaal, C. Sanchez et al., “Sirt1-deficient mice exhibit an altered cartilage phenotype,” Joint, Bone, Spine, vol. 80, no. 6, pp. 613–620, 2013. View at Publisher · View at Google Scholar · View at Scopus
79. Y. Li, W. Xiao, P. Wu et al., “The expression of SIRT1 in articular cartilage of patients with knee osteoarthritis and its correlation with disease severity,” Journal of Orthopaedic Surgery and Research, vol. 11, no. 1, p. 144, 2016. View at Publisher · View at Google Scholar · View at Scopus
80. B. L. Tang, “Sirt1 and the mitochondria,” Molecules and Cells, vol. 39, no. 2, pp. 87–95, 2016. View at Publisher · View at Google Scholar · View at Scopus
81. H. Sies, “Oxidative stress: a concept in redox biology and medicine,” Redox Biology, vol. 4, pp. 180–183, 2015. View at Publisher · View at Google Scholar · View at Scopus
82. D. Clavijo-Cornejo, K. Martinez-Flores, K. Silva-Luna et al., “The overexpression of NALP3 Inflammasome in knee osteoarthritis is associated with synovial membrane prolidase and NADPH oxidase 2,” Oxidative Medicine and Cellular Longevity, vol. 2016, Article ID 1472567, 7 pages, 2016. View at Publisher · View at Google Scholar · View at Scopus
83. G. Teixeira, C. Szyndralewiez, S. Molango et al., “Therapeutic potential of NADPH oxidase 1/4 inhibitors,” British Journal of Pharmacology, vol. 174, no. 12, pp. 1647–1669, 2017. View at Publisher · View at Google Scholar · View at Scopus
84. V. Afonso, R. Champy, D. Mitrovic, P. Collin, and A. Lomri, “Reactive oxygen species and superoxide dismutases: role in joint diseases,” Joint Bone Spine, vol. 74, no. 4, pp. 324–329, 2007. View at Publisher · View at Google Scholar · View at Scopus
85. S. B. Abramson, A. R. Amin, R. M. Clancy, and M. Attur, “The role of nitric oxide in tissue destruction,” Best Practice & Research. Clinical Rheumatology, vol. 15, no. 5, pp. 831–845, 2001. View at Publisher · View at Google Scholar · View at Scopus
86. M. De la Fuente and J. Miquel, “An update of the oxidation-inflammation theory of aging: the involvement of the immune system in oxi-inflamm-aging,” Current Pharmaceutical Design, vol. 15, no. 26, pp. 3003–3026, 2009. View at Publisher · View at Google Scholar · View at Scopus
87. Y. Henrotin, B. Kurz, and T. Aigner, “Oxygen and reactive oxygen species in cartilage degradation: friends or foes?” Osteoarthritis and Cartilage, vol. 13, no. 8, pp. 643–654, 2005. View at Publisher · View at Google Scholar · View at Scopus
88. D. M. Olszewska-Słonina, D. Matewski, G. Drewa et al., “Oxidative equilibrium in the prophylaxis of degenerative joint changes: an analysis of pre- and postoperative activity of antioxidant enzymes in patients with hip and knee osteoarthritis,” Medical Science Monitor, vol. 16, no. 5, pp. CR238–CR245, 2010. View at Google Scholar
89. J. L. Scott, C. Gabrielides, R. K. Davidson et al., “Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease,” Annals of the Rheumatic Diseases, vol. 69, no. 8, pp. 1502–1510, 2010. View at Publisher · View at Google Scholar · View at Scopus
90. K. McCulloch, G. J. Litherland, and T. S. Rai, “Cellular senescence in osteoarthritis pathology,” Aging Cell, vol. 16, no. 2, pp. 210–218, 2017. View at Publisher · View at Google Scholar · View at Scopus
91. F. M. Yakes and B. Van Houten, “Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress,” Proceedings of the National Academy of Sciences of the United States of America, vol. 94, no. 2, pp. 514–519, 1997. View at Publisher · View at Google Scholar · View at Scopus
92. A. T. Akhmedov and J. Marin-Garcia, “Mitochondrial DNA maintenance: an appraisal,” Molecular and Cellular Biochemistry, vol. 409, no. 1-2, pp. 283–305, 2015. View at Publisher · View at Google Scholar · View at Scopus
93. I. Rego-Perez, M. Fernandez-Moreno, C. Fernandez-Lopez, J. Arenas, and F. J. Blanco, “Mitochondrial DNA haplogroups: role in the prevalence and severity of knee osteoarthritis,” Arthritis and Rheumatism, vol. 58, no. 8, pp. 2387–2396, 2008. View at Publisher · View at Google Scholar · View at Scopus
94. M. Fernandez-Moreno, A. Soto-Hermida, M. E. Vazquez-Mosquera et al., “Mitochondrial DNA haplogroups influence the risk of incident knee osteoarthritis in OAI and CHECK cohorts. A meta-analysis and functional study,” Annals of the Rheumatic Diseases, vol. 76, no. 6, pp. 1114–1122, 2017. View at Publisher · View at Google Scholar · View at Scopus
95. Y. Wang, X. Zhao, M. Lotz, R. Terkeltaub, and R. Liu-Bryan, “Mitochondrial biogenesis is impaired in osteoarthritis chondrocytes but reversible via peroxisome proliferator-activated receptor γ coactivator 1α,” Arthritis & Rheumatology, vol. 67, no. 8, pp. 2141–2153, 2015. View at Publisher · View at Google Scholar · View at Scopus
96. M. Harbo, J. M. Delaisse, P. Kjaersgaard-Andersen, F. B. Soerensen, S. Koelvraa, and L. Bendix, “The relationship between ultra-short telomeres, aging of articular cartilage and the development of human hip osteoarthritis,” Mechanisms of Ageing and Development, vol. 134, no. 9, pp. 367–372, 2013. View at Publisher · View at Google Scholar · View at Scopus
97. K. Itahana, J. Campisi, and G. P. Dimri, “Mechanisms of cellular senescence in human and mouse cells,” Biogerontology, vol. 5, no. 1, pp. 1–10, 2004. View at Publisher · View at Google Scholar · View at Scopus
98. M. H. Goyns, “Genes, telomeres and mammalian ageing,” Mechanisms of Ageing and Development, vol. 123, no. 7, pp. 791–799, 2002. View at Publisher · View at Google Scholar · View at Scopus
99. C. R. Fellows, R. Williams, I. R. Davies et al., “Characterisation of a divergent progenitor cell sub-populations in human osteoarthritic cartilage: the role of telomere erosion and replicative senescence,” Scientific Reports, vol. 7, p. 41421, 2017. View at Publisher · View at Google Scholar · View at Scopus
100. M. Otero, M. Favero, C. Dragomir et al., “Human chondrocyte cultures as models of cartilage-specific gene regulation,” Methods in Molecular Biology, vol. 806, pp. 301–336, 2012. View at Publisher · View at Google Scholar · View at Scopus
101. I. Han, H. J. Park, S. C. Seong, S. Lee, I. G. Kim, and M. C. Lee, “Role of transglutaminase 2 in apoptosis induced by hydrogen peroxide in human chondrocytes,” Journal of Orthopaedic Research, vol. 29, no. 2, pp. 252–257, 2011. View at Publisher · View at Google Scholar · View at Scopus
102. K. Yudoh, v T. Nguyen, H. Nakamura, K. Hongo-Masuko, T. Kato, and K. Nishioka, “Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function,” Arthritis Research & Therapy, vol. 7, no. 2, pp. R380–R391, 2005. View at Publisher · View at Google Scholar
103. A. Freund, A. V. Orjalo, P. Y. Desprez, and J. Campisi, “Inflammatory networks during cellular senescence: causes and consequences,” Trends in Molecular Medicine, vol. 16, no. 5, pp. 238–246, 2010. View at Publisher · View at Google Scholar · View at Scopus
104. M. Xu, E. W. Bradley, M. M. Weivoda et al., “Transplanted senescent cells induce an osteoarthritis-like condition in mice,” The Journals of Gerontology: Series A, vol. 72, no. 6, pp. 780–785, 2017. View at Publisher · View at Google Scholar
105. O. H. Jeon, C. Kim, R. M. Laberge et al., “Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment,” Nature Medicine, vol. 23, no. 6, pp. 775–781, 2017. View at Publisher · View at Google Scholar · View at Scopus
106. H. W. Zhou, S. Q. Lou, and K. Zhang, “Recovery of function in osteoarthritic chondrocytes induced by p16INK4a-specific siRNA in vitro,” Rheumatology, vol. 43, no. 5, pp. 555–568, 2004. View at Publisher · View at Google Scholar · View at Scopus
107. S. G. Gao, C. Zeng, L. J. Li et al., “Correlation between senescence-associated beta-galactosidase expression in articular cartilage and disease severity of patients with knee osteoarthritis,” International Journal of Rheumatic Diseases, vol. 19, no. 3, pp. 226–232, 2016. View at Publisher · View at Google Scholar · View at Scopus
108. D. Philipot, D. Guerit, D. Platano et al., “p16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodeling in osteoarthritis,” Arthritis Research & Therapy, vol. 16, no. 1, p. R58, 2014. View at Publisher · View at Google Scholar · View at Scopus
109. G. J. Litherland, W. Hui, M. S. Elias et al., “Glycogen synthase kinase 3 inhibition stimulates human cartilage destruction and exacerbates murine osteoarthritis,” Arthritis & Rheumatology, vol. 66, no. 8, pp. 2175–2187, 2014. View at Publisher · View at Google Scholar · View at Scopus
110. H. O. Byun, H. J. Jung, Y. H. Seo et al., “GSK3 inactivation is involved in mitochondrial complex IV defect in transforming growth factor (TGF) β1-induced senescence,” Experimental Cell Research, vol. 318, no. 15, pp. 1808–1819, 2012. View at Publisher · View at Google Scholar · View at Scopus
111. M. G. Attur, M. Dave, M. Akamatsu, M. Katoh, and A. R. Amin, “Osteoarthritis or osteoarthrosis: the definition of inflammation becomes a semantic issue in the genomic era of molecular medicine,” Osteoarthritis and Cartilage, vol. 10, no. 1, pp. 1–4, 2002. View at Publisher · View at Google Scholar · View at Scopus
112. C. Melchiorri, R. Meliconi, L. Frizziero et al., “Enhanced and coordinated in vivo expression of inflammatory cytokines and nitric oxide synthase by chondrocytes from patients with osteoarthritis,” Arthritis and Rheumatism, vol. 41, no. 12, pp. 2165–2174, 1998. View at Publisher · View at Google Scholar
113. R. F. Loeser, S. R. Goldring, C. R. Scanzello, and M. B. Goldring, “Osteoarthritis: a disease of the joint as an organ,” Arthritis and Rheumatism, vol. 64, no. 6, pp. 1697–1707, 2012. View at Publisher · View at Google Scholar · View at Scopus
114. M. A. Rowe, L. R. Harper, M. A. McNulty et al., “Reduced osteoarthritis severity in aged mice with deletion of macrophage migration inhibitory factor,” Arthritis & Rheumatology, vol. 69, no. 2, pp. 352–361, 2017. View at Publisher · View at Google Scholar · View at Scopus
115. C. R. Scanzello, B. McKeon, B. H. Swaim et al., “Synovial inflammation in patients undergoing arthroscopic meniscectomy: molecular characterization and relationship to symptoms,” Arthritis and Rheumatism, vol. 63, no. 2, pp. 391–400, 2011. View at Publisher · View at Google Scholar · View at Scopus
116. J. Lieberthal, N. Sambamurthy, and C. R. Scanzello, “Inflammation in joint injury and post-traumatic osteoarthritis,” Osteoarthritis and Cartilage, vol. 23, no. 11, pp. 1825–1834, 2015. View at Publisher · View at Google Scholar · View at Scopus
117. B. J. E. de Lange-Brokaar, A. Ioan-Facsinay, G. J. V. M. van Osch et al., “Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review,” Osteoarthritis and Cartilage, vol. 20, no. 12, pp. 1484–1499, 2012. View at Publisher · View at Google Scholar · View at Scopus
118. Y. S. Li, W. Luo, S. A. Zhu, and G. H. Lei, “T cells in osteoarthritis: alterations and beyond,” Frontiers in Immunology, vol. 8, p. 356, 2017. View at Publisher · View at Google Scholar · View at Scopus
119. J. Apinun, P. Sengprasert, P. Yuktanandana, S. Ngarmukos, A. Tanavalee, and R. Reantragoon, “Immune mediators in osteoarthritis: infrapatellar fat pad-infiltrating CD8+ T cells are increased in osteoarthritic patients with higher clinical radiographic grading,” International Journal of Rheumatology, vol. 2016, Article ID 9525724, 8 pages, 2016. View at Publisher · View at Google Scholar · View at Scopus
120. C. L. Wu, J. McNeill, K. Goon et al., “Conditional macrophage depletion increases inflammation and does not inhibit the development of osteoarthritis in obese macrophage Fas-induced apoptosis-transgenic mice,” Arthritis & Rheumatology, vol. 69, no. 9, pp. 1772–1783, 2017. View at Publisher · View at Google Scholar
121. E. Kalaitzoglou, T. M. Griffin, and M. B. Humphrey, “Innate immune responses and osteoarthritis,” Current Rheumatology Reports, vol. 19, no. 8, p. 45, 2017. View at Publisher · View at Google Scholar
122. C. R. Scanzello, A. Plaas, and M. K. Crow, “Innate immune system activation in osteoarthritis: is osteoarthritis a chronic wound?” Current Opinion in Rheumatology, vol. 20, no. 5, pp. 565–572, 2008. View at Publisher · View at Google Scholar · View at Scopus
123. M. Nefla, D. Holzinger, F. Berenbaum, and C. Jacques, “The danger from within: alarmins in arthritis,” Nature Reviews Rheumatology, vol. 12, no. 11, pp. 669–683, 2016. View at Publisher · View at Google Scholar · View at Scopus
124. R. F. Schelbergen, E. J. Geven, M. H. van den Bosch et al., “Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis,” Annals of the Rheumatic Diseases, vol. 74, no. 12, pp. 2254–2258, 2015. View at Publisher · View at Google Scholar · View at Scopus
125. A. R. Amin and A. B. Islam, “Genomic analysis and differential expression of HMG and S100A family in human arthritis: upregulated expression of chemokines, IL-8 and nitric oxide by HMGB1,” DNA and Cell Biology, vol. 33, no. 8, pp. 550–565, 2014. View at Publisher · View at Google Scholar · View at Scopus
126. H. Wahamaa, H. Schierbeck, H. S. Hreggvidsdottir et al., “High mobility group box protein 1 in complex with lipopolysaccharide or IL-1 promotes an increased inflammatory phenotype in synovial fibroblasts,” Arthritis Research & Therapy, vol. 13, no. 4, p. R136, 2011. View at Publisher · View at Google Scholar · View at Scopus
127. N. Taniguchi, K. Yoshida, T. Ito et al., “Stage-specific secretion of HMGB1 in cartilage regulates endochondral ossification,” Molecular and Cellular Biology, vol. 27, no. 16, pp. 5650–5663, 2007. View at Publisher · View at Google Scholar · View at Scopus
128. N. Taniguchi, K. Kawahara, K. Yone et al., “High mobility group box chromosomal protein 1 plays a role in the pathogenesis of rheumatoid arthritis as a novel cytokine,” Arthritis and Rheumatism, vol. 48, no. 4, pp. 971–981, 2003. View at Publisher · View at Google Scholar · View at Scopus
129. J. H. Rosenberg, V. Rai, M. F. Dilisio, and D. K. Agrawal, “Damage-associated molecular patterns in the pathogenesis of osteoarthritis: potentially novel therapeutic targets,” Molecular and Cellular Biochemistry, vol. 434, no. 1-2, pp. 171–179, 2017. View at Publisher · View at Google Scholar · View at Scopus
130. J. H. Rosenberg, V. Rai, M. F. Dilisio, T. D. Sekundiak, and D. K. Agrawal, “Increased expression of damage-associated molecular patterns (DAMPs) in osteoarthritis of human knee joint compared to hip joint,” Molecular and Cellular Biochemistry, vol. 436, no. 1-2, pp. 59–69, 2017. View at Publisher · View at Google Scholar · View at Scopus
131. X. Ke, G. Jin, Y. Yang et al., “Synovial fluid HMGB-1 levels are associated with osteoarthritis severity,” Clinical Laboratory, vol. 61, no. 07/2015, pp. 809–818, 2015. View at Publisher · View at Google Scholar · View at Scopus
132. R. M. Borzi, I. Mazzetti, S. Macor et al., “Flow cytometric analysis of intracellular chemokines in chondrocytes in vivo: constitutive expression and enhancement in osteoarthritis and rheumatoid arthritis,” FEBS Letters, vol. 455, no. 3, pp. 238–242, 1999. View at Publisher · View at Google Scholar · View at Scopus
133. J. I. Pulai, H. Chen, H. J. Im et al., “NF-κB mediates the stimulation of cytokine and chemokine expression by human articular chondrocytes in response to fibronectin fragments,” The Journal of Immunology, vol. 174, no. 9, pp. 5781–5788, 2005. View at Publisher · View at Google Scholar
134. E. Assirelli, L. Pulsatelli, P. Dolzani et al., “Human osteoarthritic cartilage shows reduced in vivo expression of IL-4, a chondroprotective cytokine that differentially modulates IL-1β-stimulated production of chemokines and matrix-degrading enzymes in vitro,” PLoS One, vol. 9, no. 5, article e96925, 2014. View at Publisher · View at Google Scholar · View at Scopus
135. H. Raghu, C. M. Lepus, Q. Wang et al., “CCL2/CCR2, but not CCL5/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis,” Annals of the Rheumatic Diseases, vol. 76, no. 5, pp. 914–922, 2017. View at Publisher · View at Google Scholar · View at Scopus
136. R. M. Borzi, I. Mazzetti, L. Cattini, M. Uguccioni, M. Baggiolini, and A. Facchini, “Human chondrocytes express functional chemokine receptors and release matrix-degrading enzymes in response to C-X-C and C-C chemokines,” Arthritis and Rheumatism, vol. 43, no. 8, pp. 1734–1741, 2000. View at Publisher · View at Google Scholar
137. R. M. Borzi, I. Mazzetti, K. B. Marcu, and A. Facchini, “Chemokines in cartilage degradation,” Clinical Orthopaedics and Related Research, vol. 427, pp. S53–S61, 2004. View at Publisher · View at Google Scholar · View at Scopus
138. I. Mazzetti, G. Magagnoli, S. Paoletti et al., “A role for chemokines in the induction of chondrocyte phenotype modulation,” Arthritis and Rheumatism, vol. 50, no. 1, pp. 112–122, 2004. View at Publisher · View at Google Scholar · View at Scopus
139. R. M. Borzi, I. Mazzetti, G. Magagnoli et al., “Growth-related oncogene alpha induction of apoptosis in osteoarthritis chondrocytes,” Arthritis and Rheumatism, vol. 46, no. 12, pp. 3201–3211, 2002. View at Publisher · View at Google Scholar · View at Scopus
140. F. Bachelerie, A. Ben-Baruch, A. M. Burkhardt et al., “International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors,” Pharmacological Reviews, vol. 66, no. 1, pp. 1–79, 2013. View at Publisher · View at Google Scholar · View at Scopus
141. C. R. Scanzello, “Chemokines and inflammation in osteoarthritis: insights from patients and animal models,” Journal of Orthopaedic Research, vol. 35, no. 4, pp. 735–739, 2017. View at Publisher · View at Google Scholar · View at Scopus
142. L. Li and B. E. Jiang, “Serum and synovial fluid chemokine ligand 2/monocyte chemoattractant protein 1 concentrations correlates with symptomatic severity in patients with knee osteoarthritis,” Annals of Clinical Biochemistry, vol. 52, no. 2, pp. 276–282, 2015. View at Publisher · View at Google Scholar · View at Scopus
143. R. E. Miller, A. Belmadani, S. Ishihara et al., “Damage-associated molecular patterns generated in osteoarthritis directly excite murine nociceptive neurons through Toll-like receptor 4,” Arthritis & Rheumatology, vol. 67, no. 11, pp. 2933–2943, 2015. View at Publisher · View at Google Scholar · View at Scopus
144. J. Miotla Zarebska, A. Chanalaris, C. Driscoll et al., “CCL2 and CCR2 regulate pain-related behaviour and early gene expression in post-traumatic murine osteoarthritis but contribute little to chondropathy,” Osteoarthritis and Cartilage, vol. 25, no. 3, pp. 406–412, 2017. View at Publisher · View at Google Scholar · View at Scopus
145. M. D. Gardiner, T. L. Vincent, C. Driscoll et al., “Transcriptional analysis of micro-dissected articular cartilage in post-traumatic murine osteoarthritis,” Osteoarthritis and Cartilage, vol. 23, no. 4, pp. 616–628, 2015. View at Publisher · View at Google Scholar · View at Scopus
146. C. T. Appleton, S. E. Usmani, M. A. Pest, V. Pitelka, J. S. Mort, and F. Beier, “Reduction in disease progression by inhibition of transforming growth factor α-CCL2 signaling in experimental posttraumatic osteoarthritis,” Arthritis & Rheumatology, vol. 67, no. 10, pp. 2691–2701, 2015. View at Publisher · View at Google Scholar · View at Scopus
147. Q. Wang, A. L. Rozelle, C. M. Lepus et al., “Identification of a central role for complement in osteoarthritis,” Nature Medicine, vol. 17, no. 12, pp. 1674–1679, 2011. View at Publisher · View at Google Scholar · View at Scopus
148. M. T. Jackson, B. Moradi, M. M. Smith, C. J. Jackson, and C. B. Little, “Activation of matrix metalloproteinases 2, 9, and 13 by activated protein C in human osteoarthritic cartilage chondrocytes,” Arthritis & Rheumatology, vol. 66, no. 6, pp. 1525–1536, 2014. View at Publisher · View at Google Scholar · View at Scopus
149. T. Wei, N. H. Kulkarni, Q. Q. Zeng et al., “Analysis of early changes in the articular cartilage transcriptisome in the rat meniscal tear model of osteoarthritis: pathway comparisons with the rat anterior cruciate transection model and with human osteoarthritic cartilage,” Osteoarthritis and Cartilage, vol. 18, no. 7, pp. 992–1000, 2010. View at Publisher · View at Google Scholar · View at Scopus
150. S. L. Hulin-Curtis, J. L. Bidwell, and M. J. Perry, “Association between CCL2 haplotypes and knee osteoarthritis,” International Journal of Immunogenetics, vol. 40, no. 4, pp. 280–283, 2013. View at Publisher · View at Google Scholar · View at Scopus
151. V. Dasa, J. M. Kramer, S. L. Gaffen, K. L. Kirkwood, and W. M. Mihalko, “Is monocyte chemotactic protein 1 elevated in aseptic loosening of TKA? A pilot study,” Clinical Orthopaedics and Related Research, vol. 470, no. 7, pp. 1879–1884, 2012. View at Publisher · View at Google Scholar · View at Scopus
152. F. Wei, D. C. Moore, L. Wei et al., “Attenuation of osteoarthritis via blockade of the SDF-1/CXCR4 signaling pathway,” Arthritis Research & Therapy, vol. 14, no. 4, p. R177, 2012. View at Publisher · View at Google Scholar · View at Scopus
153. M. Schiraldi, A. Raucci, L. M. Munoz et al., “HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4,” The Journal of Experimental Medicine, vol. 209, no. 3, pp. 551–563, 2012. View at Publisher · View at Google Scholar · View at Scopus
154. Z. Huang and V. B. Kraus, “Does lipopolysaccharide-mediated inflammation have a role in OA?” Nature Reviews Rheumatology, vol. 12, no. 2, pp. 123–129, 2015. View at Publisher · View at Google Scholar · View at Scopus
155. T. V. Stabler, Z. Huang, E. Montell, J. Verges, and V. B. Kraus, “Chondroitin sulphate inhibits NF-κB activity induced by interaction of pathogenic and damage associated molecules,” Osteoarthritis and Cartilage, vol. 25, no. 1, pp. 166–174, 2017. View at Publisher · View at Google Scholar · View at Scopus
156. K. H. Collins, H. A. Paul, R. A. Reimer, R. A. Seerattan, D. A. Hart, and W. Herzog, “Relationship between inflammation, the gut microbiota, and metabolic osteoarthritis development: studies in a rat model,” Osteoarthritis and Cartilage, vol. 23, no. 11, pp. 1989–1998, 2015. View at Publisher · View at Google Scholar · View at Scopus
157. P. Lopez de Figueroa, M. K. Lotz, F. J. Blanco, and B. Carames, “Autophagy activation and protection from mitochondrial dysfunction in human chondrocytes,” Arthritis & Rheumatology, vol. 67, no. 4, pp. 966–976, 2015. View at Publisher · View at Google Scholar · View at Scopus
158. J. K. Meckes, B. Carames, M. Olmer et al., “Compromised autophagy precedes meniscus degeneration and cartilage damage in mice,” Osteoarthritis and Cartilage, vol. 25, no. 11, pp. 1880–1889, 2017. View at Publisher · View at Google Scholar