Damaging Effects of Bisphenol A on the Kidney and the Protection by Melatonin: Emerging Evidences from In Vivo and In Vitro Studies

Table 1

Effects of various concentrations of bisphenol A on body weight, kidney weight, and food intake.

Experimental groups	Initial BW (g)	Food intake (g/day)	BW gain (%)	KW/BW ()
Veh	237.00 ± 4.79	21.21 ± 0.83	56.87 ± 6.10	0.53 ± 0.02
BPA50	232.50 ± 9.46	20.29 ± 0.48	49.56 ± 5.32	0.60 ± 0.01
BPA100	242.50 ± 2.50	19.04 ± 1.28	30.96 ± 2.78	0.68 ± 0.03
BPA150	235.00 ± 11.90	18.04 ± 2.85	12.95 ± 7.14	0.80 ± 0.06^†

Data are presented as the mean ± SEM (). Veh: vehicle-treated group; BPA (50, 100, and 150): bisphenol A-treated group at 50, 100, and 150 mg/kg i.p., respectively, for 5 weeks; BW: body weight; KW: kidney weight. versus Veh, versus BPA50, versus BPA100.