Damaging Effects of Bisphenol A on the Kidney and the Protection by Melatonin: Emerging Evidences from In Vivo and In Vitro Studies

Table 2

Effects of melatonin on body weight, kidney weight, and food intake in BPA-exposed rats.

Experimental groups	Initial BW (g)	Food intake (g/day)	BW gain (%)	KW/BW ()
Veh	231.88 ± 1.32	22.14 ± 0.59	57.65 ± 2.83	0.61 ± 0.01
BPA	233.13 ± 2.66	21.29 ± 0.59	46.04 ± 2.97	0.78 ± 0.04
BPA + MEL	231.88 ± 2.98	25.50 ± 0.44	54.16 ± 2.18	0.72 ± 0.01

Data are presented as the mean ± SEM (). Veh: vehicle-treated group; BPA: bisphenol A-treated group at 50 mg/kg i.p.; BPA + MEL: - (50 mg/kg, i.p.) plus melatonin- (10 mg/kg, i.p.) treated group for 5 weeks; BW: body weight; KW: kidney weight. versus Veh, versus BPA.