Falcarinol Is a Potent Inducer of Heme Oxygenase-1 and Was More Effective than Sulforaphane in Attenuating Intestinal Inflammation at Diet-Achievable Doses

<table class="figure-group"><tr class="fig-image" id="a"><td><object data="https://static.hindawi.com/articles/omcl/volume-2018/3153527/figures/3153527.fig.001a.svgz" name="3153527.fig.001a" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(a) </b>Signaling</td></tr><tr class="fig-image" id="b"><td><object data="https://static.hindawi.com/articles/omcl/volume-2018/3153527/figures/3153527.fig.001b.svgz" name="3153527.fig.001b" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(b) </b>Physicochemical</td></tr></table>

<div>Effects of LPS. (1) LPS binding to the toll-like receptor-4 (TLR4) receptor initiates signaling to disrupt the inhibitor protein IKK association with proinflammation transcription factor NF<i>κ</i>B. (2) Free NF<i>κ</i>B translocates to the nucleus to increase the transcription of proinflammatory cytokines Tnf<i>α</i>, IL-6, IL-1<i>β</i>, etc. (3) LPS causes plasma membrane disruption in red blood cells releasing free heme. (4) Ho-1 breaks down free heme to equimolar amounts of CO, Fe, and biliverdin which is enzymatically converted to bilirubin, forming a redox couple.</div>

Oxidative Medicine and Cellular Longevity

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Figure 1: Falcarinol Is a Potent Inducer of Heme Oxygenase-1 and Was More Effective than Sulforaphane in Attenuating Intestinal Inflammation at Diet-Achievable Doses 

Figure 1 | Falcarinol Is a Potent Inducer of Heme Oxygenase-1 and Was More Effective than Sulforaphane in Attenuating Intestinal Inflammation at Diet-Achievable Doses 