Coenzyme Q10 Prevents Senescence and Dysfunction Caused by Oxidative Stress in Vascular Endothelial Cells

Figure 1

Preincubation with CoQ₁₀H₂ prevented H₂O₂-induced senescence of HUVECs. (a) Representative images of SA-β-Gal-stained cells from each group (control, CoQ₁₀H₂, H₂O₂, and CoQ₁₀H₂ + H₂O₂). (b) Percentage of SA-β-Gal-positive cells (). (c) Expression levels of PAI-1 mRNA (). (d) Expression of genes involved in the senescence-associated secretory phenotype. Histograms show fold change in mRNA level relative to control cells (n = 6–9). , , and ; one-way ANOVA followed by Tukey’s test.

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