Effects of Vitamin D3 on the NADPH Oxidase and Matrix Metalloproteinase 9 in an Animal Model of Global Cerebral Ischemia

Table 1

Levels of GSH, MDA, and O₂^·− in the synaptosomal fraction of different brain structures in group I () (sham-operated animals, which underwent the same surgical procedure without vessel occlusion (control)), group II () (subjected to ischemia/reperfusion (I/R)), and group III () (treated with vitamin D3 prior to I/R ().

Brain structure		Cortex	Hippocampus
Parameter	Group
GSH (mmol/mg protein)	Ctrl	12.77 ± 0.59	12.06 ± 0.90
	I/R	7.07 ± 1.03	8.03 ± 1.14
		4.13 ± 0.62	6.80 ± 1.20
MDA (mmol/mg protein)	Ctrl	35.22 ± 1.63	29.68 ± 0.64
	I/R	51.33 ± 5.73	38.24 ± 2.61
		39.51 ± 4.19	32.19 ± 2.77
O2^·− (nM/min/mg protein)	Ctrl	8.09 ± 0.34	9.82 ± 0.25
	I/R	10.88 ± 0.29	11.47 ± 0.34
		8.93 ± 0.33	10.19 ± 0.28

Results are presented as mean ± SE. versus control, versus control, versus I/R, and versus I/R.