Hydrogen Sulfide Alleviates Acute Myocardial Ischemia Injury by Modulating Autophagy and Inflammation Response under Oxidative Stress

Figure 7

NaHS treatment alleviated apoptosis and autophagy in the ischemic myocardium from SOD1 KO mice. (a) Representative images and quantitative analysis of superoxide levels in SOD1 KO mice after AMI surgery with or without 50 μmol/kg NaHS treatment. Scale . (b) Representative images and quantitative analysis of the infarct size with or without NaHS treatment. The white area represents INF. LV: left ventricle; INF: infarct area. (c) Representative images and quantitative analysis of apoptotic cells in the myocardium of SOD1 KO mice after AMI surgery with or without NaHS treatment. TUNEL staining is shown in red. Nuclei are shown in blue. Scale . (d) Representative blots and quantitative analysis of LC3II/LC3I, Bax, and Bcl2. (e) Representative images of TEM results are shown. Red arrows indicate autophagic vacuoles. Scale . Values are , in each group. , , and .

(a)

(b)

(c)

(d)

(e)