Repeated Cycles of Binge-Like Ethanol Intake in Adolescent Female Rats Induce Motor Function Impairment and Oxidative Damage in Motor Cortex and Liver, but Not in Blood

Figure 1

Experimental schedule of binge-like ethanol treatment in adolescent rats. Each cycle of binge-like ethanol administration consisted of a daily gavage administration of ethanol (3 g/kg/day) (or water to control group) for 3 consecutive days weekly. Initially, the immediate postadministration effects of either a single or repeated binge-like ethanol episodes in adolescence were assessed. Female rats underwent one cycle of binge-like ethanol treatment at postnatal day 35 (PND35) or 4 cycles of binge-like episodes (PND35–58). After motor behavioral analysis, rats were sacrificed for markers of biochemical analysis and hepatic histopathology.