Repeated Cycles of Binge-Like Ethanol Intake in Adolescent Female Rats Induce Motor Function Impairment and Oxidative Damage in Motor Cortex and Liver, but Not in Blood

Figure 2

Impact of adolescent binge-ethanol exposure on motor behavior of female rats. The analysis of the total distance traveled accessed the horizontal locomotor activity, whereas the number of rearing informed the vertical locomotor activity, both measures being derived from the track plots in the open-field arena (a). (b) The descent time from vertical beam to the platform base at the pole test is shown as a measure of the kinetics of movement. (c) The latency to first fall on the cylinder of the rotarod apparatus is illustrated as a measure of the motor coordination and balance by forced locomotor activity in the rotarod test. (d) The number of slips to cross the series of graduated beams (square and round) is shown to access the motor learning, coordination, and balance by spontaneous locomotor activity in the beam-walking test. Data are mean ± SEM of rats per group. , , and vs. age-matched control; and vs. ethanol-treated after 1 binge-like cycle, all assessed using a Fisher-LSD test after two-way ANOVA.

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