The Identification of Core Gene Expression Signature in Hepatocellular Carcinoma

Table 3

KEGG pathway analysis of differentially expressed genes associated with hepatocellular carcinoma.

Category	Term	Count	%	value	Genes	FDR
Downregulated DEGs	hsa04978: mineral absorption	9	0.03	2.22E − 07	MT1M, SLC5A1, MT2A, MT1E, TRPV6, MT1H, MT1X, MT1G, and MT1F	2.68E − 04
	hsa00830: retinol metabolism	10	0.03	2.90E − 07	CYP3A4, CYP4A11, CYP2B6, CYP2C8, ADH4, ADH1B, CYP26A1, CYP2A6, CYP1A2, and RDH16	3.50E − 04
	hsa00232: caffeine metabolism	4	0.01	2.79E − 05	XDH, NAT2, CYP2A6, and CYP1A2	0.03
	hsa00982: drug metabolism-cytochrome P450	8	0.03	4.75E − 05	CYP3A4, CYP2B6, CYP2C8, ADH4, ADH1B, CYP2A6, CYP2E1, and CYP1A2	0.06
	hsa05204: chemical carcinogenesis	8	0.03	1.35E − 04	CYP3A4, CYP2C8, ADH4, NAT2, ADH1B, CYP2A6, CYP2E1, and CYP1A2	0.16
Upregulated DEGs	hsa04110: cell cycle	8	0.05	9.30E − 07	CCNB1, CDK1, CCNB2, BUB1, TTK, PTTG1, SFN, and CDC25C	9.18E − 04
	hsa04115: p53 signaling pathway	6	0.04	1.03E − 05	CCNB1, CDK1, CCNB2, RRM2, SFN, and GTSE1	0.01
	hsa04914: progesterone-mediated oocyte maturation	5	0.03	5.69E − 04	CCNB1, CDK1, CCNB2, BUB1, and CDC25C	0.56
	hsa04114: oocyte meiosis	4	0.03	0.01	CDK1, BUB1, PTTG1, and CDC25C	11.64

KEGG: Kyoto Encyclopedia of Genes and Genomes; FDR: false discovery rate.