The Identification of Core Gene Expression Signature in Hepatocellular Carcinoma

Table 4

The enriched pathways of top 3 modules.

Module	Term	value	FDR	Genes
Module 1	Cell cycle	2.66E − 08	1.96E − 05	CCNB1, CDK1, CCNB2, BUB1, TTK, PTTG1, and CDC25C
	ATP binding	3.86E − 07	3.59E − 04	CDK1, KIF4A, NEK2, KIF18B, TTK, CENPE, PBK, KIF2C, BUB1, TOP2A, MELK, TRIP13, and KIF20A
	Kinesin, motor region, and conserved site	1.54E − 06	0.0016579	KIF2C, KIF4A, KIF18B, CENPE, and KIF20A
	Kinesin, motor domain	2.30E − 06	0.00247205	KIF2C, KIF4A, KIF18B, CENPE, and KIF20A
	p53 signaling pathway	3.59E − 06	0.002649002	CCNB1, CDK1, CCNB2, RRM2, and GTSE1
Module 2	Cytochrome P450, conserved site	4.98E − 15	3.11E − 12	CYP3A4, CYP4A11, CYP2B6, CYP2C8, CYP26A1, CYP2A6, and CYP1A2
	Cytochrome P450	9.23E − 15	5.74E − 12	CYP3A4, CYP4A11, CYP2B6, CYP2C8, CYP26A1, CYP2A6, and CYP1A2
	Monooxygenase	3.58E − 14	2.84E − 11	CYP3A4, CYP4A11, CYP2B6, CYP2C8, CYP26A1, CYP2A6, and CYP1A2
	Organelle membrane	6.92E − 14	3.79E − 11	CYP3A4, CYP4A11, CYP2B6, CYP2C8, CYP26A1, CYP2A6, and CYP1A2
	Metal ion-binding site: iron (heme axial ligand)	8.64E − 14	6.13E − 11	CYP3A4, CYP4A11, CYP2B6, CYP2C8, CYP26A1, CYP2A6, and CYP1A2
Module 3	Metal-thiolate cluster	2.15E − 17	1.80E − 14	MT1M, MT2A, MT1E, MT1H, MT1G, MT1X, MT1F
	Metallothionein, vertebrate, and metal binding site	2.35E − 17	1.91E − 14	MT1M, MT2A, MT1E, MT1H, MT1G, MT1X, and MT1F
	Metallothionein, vertebrate	5.17E − 17	4.19E − 14	MT1M, MT2A, MT1E, MT1H, MT1G, MT1X, and MT1F
	Metallothionein domain	5.17E − 17	4.19E − 14	MT1M, MT2A, MT1E, MT1H, MT1G, MT1X, and MT1F
	Metallothionein superfamily, eukaryotic	5.17E − 17	4.19E − 14	MT1M, MT2A, MT1E, MT1H, MT1G, MT1X, and MT1F