Dysfunction of Nrf2-ARE Signaling Pathway: Potential Pathogenesis in the Development of Neurocognitive Impairment in Patients with Moderate to Severe Obstructive Sleep Apnea-Hypopnea Syndrome

Table 12

Multiple linear regression of age, sex, BMI, education, smoking index, PSG parameters, and Trx and SOD levels for the prediction of BVMT-R test results.

Mode	Unstandardized coefficients		Standardized coefficients		Sig.	95.0% confidence interval for B
	B	Std. error	Beta			Lower bound	Upper bound
1 constant	26.636	34.324		0.776	0.443	−43.119	96.390
Sex	−2.116	2.780	−0.104	−0.761	0.452	−7.765	3.534
Age (y)	−0.162	0.108	−0.226	−1.497	0.144	−0.382	0.058
Education (y)	0.779	0.236	0.420	3.308	0.002	0.301	1.258
Smoking index	0.003	0.002	0.175	1.204	0.237	−0.002	0.008
AHI	−0.084	0.089	−0.233	−0.949	0.350	−0.265	0.096
ODI	0.065	0.083	0.197	0.785	0.438	−0.104	0.235
LSaO2	−0.080	0.098	−0.191	−0.815	0.421	−0.279	0.119
MSaO2	−0.086	0306	−0.061	−0.281	0.780	−0.707	0.535
TSat90	−0.035	0.119	−0.088	−0.293	0.771	−0.227	0.207
REM%	−0.193	0.169	−0.174	−1.138	0.263	−0.537	0.151
BMI	−0.086	0.324	−0.40	−0.266	0.792	−0.745	0.572
Trx	0.996	0.376	0.454	2.65	0.012	0.232	1.760
SOD	−0.008	0.010	−0.139	−0.822	0.417	−0.029	0.012

Dependent variable: BVMT-R score. SOD, superoxide dismutase; Trx, thioredoxin; AHI, apnea-hypopnea index; ODI, oxygen desaturation index; LSaO₂, lowest oxygen saturation; MSaO₂, mean oxygen saturation; TSat90, % of time SaO₂ < 90%; REM%, percent of rapid eye movement in total sleep time; BMI, body mass index; SOD, superoxide dismutase.