Dysfunction of Nrf2-ARE Signaling Pathway: Potential Pathogenesis in the Development of Neurocognitive Impairment in Patients with Moderate to Severe Obstructive Sleep Apnea-Hypopnea Syndrome

Table 2

Comparison of basic data between patients with OSAHS and healthy controls.

	Control group ()	OSAHS group ()	value
Age (y)	41 (35–50)	48 (32–51)	0.301^b
Men/women ()	14/6	16/4	0.716^c
Education (y)	13 (10–16)	12 (10–16)	0.429^b
BMI (kg/m^2)	27.8 ± 1.6	28.2 ± 3.6	0.626^a
Smoking index	0 (0–0)	300 (0–675)	0.060^b
Drinking index	0 (0–0)	0 (0–225)	0.640^b
AHI (events/hour)	1.8 (0.8–2.4)	45.6 (27–63)	≤0.001^b
ODI (events/hour)	1.0 (0.6–2.2)	47.6 (20–69)	≤0.001^b
LSaO2 (%)	93 (91–94)	76 (60–80)	≤0.001^b
MSaO2 (%)	96 (96-97)	96 (90–96)	0.024^b
TSat90	0 (0–0)	3.25 (5.8–26.3)	≤0.001^b
REM%	20.8 ± 2.97	9.05 ± 5.35	≤0.001^a
ESS	8.5 (7–10)	13.5 (9.5–19)	≤0.001^b

BMI: body mass index; ESS: Epworth Sleepiness Scale; TSat90, % of time SaO₂ < 90%; REM%, percent of rapid eye movement in total sleep time. ^aStudent’s t-test (data were presented as mean ± standard deviation (SD)). ^bMann–Whitney U test (data were presented as median (minimum-maximum)). ^cChi-square test (data were presented as number of people). and .