Dysfunction of Nrf2-ARE Signaling Pathway: Potential Pathogenesis in the Development of Neurocognitive Impairment in Patients with Moderate to Severe Obstructive Sleep Apnea-Hypopnea Syndrome

Table 4

Comparison of neurocognitive function between the control group and OSAHS group.

	Control group ()	OSAHS group ()	value
TMT: part A	33.6 ± 9.06	44.3 ± 17.64	≤0.001^a
Symbol coding	55.8 ± 14.6	44.1 ± 14.1	0.001^a
HVLT-R	26 (21–30)	23 (16–27)	0.007^b
WMS-III: spatial span	18 (16–19)	16 (13–17)	0.002^b
NAB: mazes	18.2 ± 5.0	13.1 ± 6.2	≤0.001^a
BVMT-R	22 (18–30)	20 (11–23)	0.002^b
Category Fluency Test	23.9 ± 5.6	18.3 ± 6.2	≤0.001^a
CPT-IP-2D	3.62 (3.17–4.24)	3.08 (1.95–3.68)	0.001^b
CPT-IP-3D	3.18 (2.60–3.34)	2.34 (1.43–3.20)	0.009^b
CPT-IP-4D	1.88 ± 0.79	1.40 ± 0.68	0.008^a
CPT-IP-mean	2.76 ± 0.7	2.17 ± 0.8	0.002^a
SCWT-word	95 (83–100)	80 (63–95)	0.003^b
SCWT-color	69.4 ± 14.14	54.2 ± 19.1	≤0.001^a
SCWT-color-word	41.8 ± 7.81	30.6 ± 12.5	≤0.001^a

TMT: part A, Trail Making Test: part A; HVLT-R, Hopkins Verbal Learning Test-Revised; WMS-III: spatial span, Wechsler Memory Scale-III: spatial span; NAB: mazes, Neurological Assessment Battery: mazes; BVMT-R, Brief Visuospatial Memory Test-Revised; CPT-IP, Continuous Performance Test-Identical Pairs; SCWT, Stroop Color and Word Test; ^aStudent’s t-test (data were presented as mean ± SD). ^bMann–Whitney U test (data were presented as median (minimum-maximum)). .