Dysfunction of Nrf2-ARE Signaling Pathway: Potential Pathogenesis in the Development of Neurocognitive Impairment in Patients with Moderate to Severe Obstructive Sleep Apnea-Hypopnea Syndrome

Table 6

The expression difference of Nrf2 and HO-1 mRNA and protein between groups.

	Control group ()	OSAHS group ()	value
Nrf2 mRNA	0.30 ± 0.097	0.16 ± 0.05	≤0.001^a
HO-1 mRNA	0.050 (0.042–0.065)	0.039 (0.029–0.048)	0.004^b
Total Nrf2 protein	0.53 ± 0.088	0.32 ± 0.073	≤ 0.001^a
Nrf2 protein at the nucleus	0.66 ± 0.15	0.28 ± 0.07	≤0.001^a
HO-1 protein	0.62 ± 0.12	0.30 ± 0.13	≤0.001^a

Nrf2, nuclear factor erythroid 2-related factor 2; HO-1, heme oxygenase-1. ^aStudent’s t-test (data are presented as mean ± SD). ^bMann–Whitney U test (data are presented as median (minimum-maximum)). .