Dysfunction of Nrf2-ARE Signaling Pathway: Potential Pathogenesis in the Development of Neurocognitive Impairment in Patients with Moderate to Severe Obstructive Sleep Apnea-Hypopnea Syndrome

Table 9

Correlation of Nrf2 and HO-1 mRNA and protein expression in PBMCs and sleeping breathing parameters in the OSAHS group.

	Nrf2 mRNA	HO-1 mRNA	Total Nrf2 protein	Nuclear Nrf2 protein	HO-1 protein
AHI		0.236	0.512	−0.625	−0.376
		0.380	0.043	0.010	0.151
ODI		0.269	0.486	−0.518	−0.584
		0.313	0.057	0.040	0.017
LSaO2		−0.265	−0.549	0.610	0.550
		0.322	0.028	0.012	0.027
MSaO2		−0.153	−0.439	0.424	0.565
		0.573	0.089	0.102	0.023
REM%		−0.147	0.202	0.265	0.026
		0.586	0.454	0.321	0.924
TSat90 (%)		0.139	0.534	−0.588	−0.582
		0.609	0.033	0.017	0.018

Data are presented as correlation coefficients (r) and p values. Partial correlation analysis (adjusted covariates: age, education, sex, BMI, and smoking index. . AHI, apnea-hypopnea index; ODI, oxygen desaturation index; LSaO₂, lowest oxygen saturation; MSaO₂, mean oxygen saturation; TSat90, % of time SaO₂ < 90%; REM%, percent of rapid eye movement in total sleep time.