Regulation of Tumor Progression by Programmed Necrosis

Figure 1

Metabolic stress-induced necrosis is closely associated with tumor progression and aggressiveness. (a) Cell death is generally classified into three categories: apoptosis, autophagy, and necrosis, which are characterized by the distinct biochemical and morphological changes listed. (b) Diagram depicting how necrosis promotes tumor progression and aggressiveness by releasing the proinflammatory and angiogenic cytokine HMGB1, which can contribute to malignancy through increasing the probability of proto-oncogenic mutations or epigenetic alterations.

(a)

(b)