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Oxidative Medicine and Cellular Longevity
Volume 2018, Article ID 3617508, 11 pages
Review Article

Autophagy Is a Promoter for Aerobic Exercise Performance during High Altitude Training

1Graduate School, Wuhan Sports University, Wuhan 430079, China
2College of Sports, Hubei University of Science and Technology, Xianning 437100, China
3Tianjiu Research and Development Center for Exercise Nutrition and Foods, Hubei Key Laboratory of Sport Training and Monitoring, College of Health Science, Wuhan Sports University, Wuhan 430079, China

Correspondence should be addressed to Ning Chen; moc.liamg@015nehcn

Received 18 January 2018; Revised 10 March 2018; Accepted 15 March 2018; Published 5 April 2018

Academic Editor: Silvana Hrelia

Copyright © 2018 Ying Zhang and Ning Chen. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


High altitude training is one of the effective strategies for improving aerobic exercise performance at sea level via altitude acclimatization, thereby improving oxygen transport and/or utilization. But its underlying molecular mechanisms on physiological functions and exercise performance of athletes are still vague. More recent evidence suggests that the recycling of cellular components by autophagy is an important process of the body involved in the adaptive responses to exercise. Whether high altitude training can activate autophagy or whether high altitude training can improve exercise performance through exercise-induced autophagy is still unclear. In this narrative review article, we will summarize current research advances in the improvement of exercise performance through high altitude training and its reasonable molecular mechanisms associated with autophagy, which will provide a new field to explore the molecular mechanisms of adaptive response to high altitude training.