Oxidative Medicine and Cellular Longevity / 2018 / Article / Tab 4 / Review Article
Biological Effects of Tetrahydroxystilbene Glucoside: An Active Component of a Rhizome Extracted from Polygonum multiflorum Table 4 Protective effects against cerebral ischemia injury.
Experimental model Dose Effects and possible mechanism Reference number OGD-R-induced cell; MCAO mice 25 μ M; 15 and 40 mg/kg ↓ Neuronal injury; ↓ intracellular ROS; ↓ [Ca2+ ]i , ↑ MMP; ↓ brain infarct volume; ↓ cell apoptosis [18 ] Rat 0.038, 0.114, and 0.342 g/kg ↑ GSH-PX and SOD activities; ↓ MDA content [88 ] Gerbils 0.038, 0.114, and 0.342 g/kg ↓ Binding force of NMDA receptor; ↓ intracellular [Ca2+ ]i [89 ] Rats 60 mg/kg ↑ The protein expression of HIF-1α and EPO [91 ] Rats 30, 60, and 120 mg/kg ↓ Cell apoptosis; ↑ Bcl-2; ↓ Bax [92 ] Rats 30, 60, and 120 mg/kg ↓ AChE activity; ↑ the expression of protein PP-2A and MAP-2 [95 ] Rats 30, 60, and 120 mg/kg Promoted postoperative recovery in rats; ↓ volume of cerebral infarcts; improving neurological dysfunction; ↑ microvessel density in the brain; ↑ CD31 expression; ↑ levels of VEGF, Ang 1, and Tie-2 [12 ]