Biological Effects of Tetrahydroxystilbene Glucoside: An Active Component of a Rhizome Extracted from Polygonum multiflorum

Table 5

Effects on inflammatory disease.

Experimental model	Dose	Effects and possible mechanism	Reference number
Mice	10, 30, and 60 mg/kg	Attenuates acetic acid-induced colon lesions; reverses body weight loss, and improves histopathological changes; ↓ the content of MDA; ↑ the mRNA and protein levels of PPAR-γ; inhibition of the NF-κB pathway; ↓ the protein overexpression of the TNF-α, IL-6, and COX-2	[123]
RAW264.7 macrophage cells	1, 10, and 100 μmol/l	↓ COX-2 enzyme activity and expression	[126]
Microglia BV2 cell lines	20–80 μM	↓ NADPH oxidase activation; ↓ ROS production	[130]